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Clinical Trials in China / NCT07178015
Enrolling by invitation Observational

A Cohort Study on Cardiovascular and Cerebrovascular Outcomes

NCT07178015 · tracked via the Priya Life Science China tracker
Sponsor
Sun Yat-sen University
Phase
Observational
Started
2021-12-30
Last updated
2025-12-15

Condition(s) studied

StrokeAtheroscleroses

Investigational drug(s) / intervention(s)

ultrasound scanning

ultrasound scanning: Ultrasound (US) is one of the most frequently utilized methods in carotid screening worldwide, because of its noninvasive and radiation-free nature and advantages of cost-effectiveness and convenience。

Study summary

A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed. Ultrasound (US) is one of the most frequently utilized methods in carotid screening worldwide. However, the clinical utility of US-based carotid plaque-RADS in refining stroke risk stratification beyond conventional stenosis grading has not been thoroughly validated. This study intends to conduct a bidirectional cohort study. In the retrospective part, we will collect relevant clinical data of patients and combine the Plaque-RADS scoring system to establish a risk regression prediction model for cardiovascular and cerebrovascular events in patients with carotid plaques. We will also prospectively collect a batch of patient data and incorporate ultrasound vector flow imaging and vascular hardness analysis to conduct a prospective cohort study, and further verify the accuracy and effectiveness of the model. Through this research, we aim to identify high-risk patients early, provide early intervention and treatment for high-risk individuals, and reduce the mortality and disability rates of cardiovascular and cerebrovascular diseases.

Eligibility

Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria: * patients with asymptomatic carotid plaques Exclusion Criteria: * suboptimal image quality or insufficiently detailed examination affecting analysis accuracy; * recent hemorrhagic cerebral infarction, intracranial hemorrhage, or intracranial neoplasms; * a prior history of neck radiotherapy or ipsilateral carotid artery surgical/stent procedures; * lost to follow-up monitoring or had an estimated survival time \<12 months.

Primary outcome measure(s)

  • the occurrence of symptomatic events — 12 months after carotid ultrasound examinations

Trial sites (1)

FacilityCityRegionStatus
the Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong

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Other trials for the same condition

Study on the Incremental Predictive Value of Early Resting-State EEG Phenotypes for Functional Prognosis and Risk Stratification in Acute Ischemic Stroke Starting soon
Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes Recruiting
Art Therapy and Its Effect on Motor Function Rehabilitation in the Subacute Phase of Stroke Recovery Recruiting
Validation of the Accuracy of a Novel POCT Dry Electrolyte Analysis System in the Acute Care Setting Recruiting
Early Aggressive Strategy for Treatment of Lipid-Lowering in Acute Ischemic Stroke Delivered With Endovascular Therapy for Large Artery Occlusion Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07178015 on ClinicalTrials.gov ↗ ← All trials in China