Multimodal Imaging Assessment After Revascularization in Patients With Acute Myocardial Infarction

Condition(s) studied

Study summary

This prospective cohort study will enroll 20 patients clinically diagnosed with first-time acute myocardial infarction (AMI) who underwent interventional procedures (including percutaneous coronary intervention \[PCI\] and balloon angioplasty) at the Affiliated Hospital of Qingdao University. Patient data, including routine blood and urine tests, blood biochemistry, electrocardiograms (ECG), imaging studies, and interventional procedure records, will be collected to assess eligibility for enrollment. The study procedures include patient screening and enrollment, obtaining informed consent, baseline assessment (including medical history, laboratory tests, ECG, etc.), an ¹⁸F-Pentixafor PET/MR examination, and follow-up. Images will be blindly assessed by at least two specialized physicians from the Radiology and Nuclear Medicine departments. The study aims to investigate the utility of ¹⁸F-Pentixafor PET/MR in evaluating coronary microcirculatory function, cardiac function, myocardial viability, myocardial inflammatory response, and the efficacy of interventional therapy in AMI patients post-procedure. Additionally, it will perform risk stratification and prognostic analysis for the enrolled patients.

Eligibility

Primary outcome measure(s)

• The myocardial uptake of 18F-Pentixafor was quantified using SUVmax and SUVmean values derived from PET imaging. — At baseline (within 1 week of enrollment)
• Left ventricular ejection fraction (LVEF) assessed by cardiac MRI to evaluate left ventricular function — At baseline (within 1 week of enrollment)
• Infarct Characterization — At baseline (within 1 week of enrollment)
  Late gadolinium enhancement (LGE) images were used to calculate infarct size (IS).

Trial sites (1)

More The Affiliated Hospital of Qingdao University trials in China

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