Clinical Trials in China / NCT07125339
Starting soon
Observational
High-resolution Magnetic Resonance Vessel Wall Imaging of Plaques
NCT07125339 · tracked via the Priya Life Science China tracker
Condition(s) studied
Intracranial Atherosclerotic Stenosis
Study summary
The primary objective of this study is to investigate the predictive value of High-resolution magnetic resonance vessel wall imaging for future stroke occurrence in patients with moderate to severe intracranial and extracranial artery stenosis.
The secondary objective is to explore the predictive value of baseline high-resolution magnetic resonance vessel wall imaging for plaque progression.
Eligibility
Inclusion Criteria:
* At least 18 years old;
* Medium or severe stenosis of the internal carotid artery, middle cerebral artery, V4 segment of vertebral artery or basilar artery \[stenosis degree: 50% \~ 99%, confirmed by CTA, MRA or DSA\];
* Accept high resolution magnetic resonance angiography; The patient or the legal representative of the patient is able and willing to sign an informed consent form
Exclusion Criteria:
* Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.;
* There are contraindications to MRI, such as claustrophobia, metal implants, etc.;
* Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal);
* Patients with severe cardiopulmonary diseases were considered unsuitable for this study;
* Gadolinium contrast agent allergy;
* Participants who were unable to complete the study due to mental illness, cognitive or emotional disorder.
Primary outcome measure(s)
- Lumen Stenosis Rate — 2024.08-2027.12
The lumen stenosis rate is calculated using the 3D TOF-MRA measurement of the vertebral-basilar artery's narrowest diameter and the normal diameter at the proximal end. The calculation follows the Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) standard formula: Lumen Stenosis Rate = \[1- (Narrowest Diameter / Normal Diameter at Proximal End)\] × 100% - Identify different plaque components — 2024.08-2027.12
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Shanghai Jiao Tong University Affiliated Sixth People's Hospital | Shanghai | China |
More Shanghai Jiao Tong University Affiliated Sixth People's Hospital trials in China
Other trials for the same condition
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07125339 on ClinicalTrials.gov ↗ ← All trials in China