A Study of SKB107 in Advanced Solid Tumors With Bone Metastases

Inclusion Criteria: 1. The age should be between 18 years and 75 years at the time of signing the informed consent form (ICF); 2. The Eastern Cooperative Oncology Group (ECOG) performance status score should be ≤ 1; 3. The expected survival period should be ≥ 3 months; 4. Phase Ia: Subjects with advanced solid tumor bone metastases diagnosed by histology or cytology; and the subjects have failed standard treatment, or have no standard treatment, or are intolerant or not applicable to standard treatment; 5. Phase Ib: Subjects with advanced mCRPC diagnosed by histology or cytology; 6. Before the first administration, a 99mTc-MDP bone scan diagnosed multiple bone metastases, and at least one site was confirmed by CT or MRI; 7. Have adequate organ and bone marrow functions; 8. For subjects with reproductive capacity, take effective medical contraceptive measures during the study treatment and within 6 months after the last administration; 9. The subjects voluntarily join this study, sign the informed consent form, and can comply with the visit and related procedures stipulated in the protocol. Exclusion Criteria: 1. The washout period before the first administration of the study drug was insufficient. 2. Previous received similar radionuclide internal irradiation treatment. 3. Previous received or planned to receive during the study period semi-body external radiotherapy targeting bone metastases. 4. Known "super bone imaging". 5. Known spinal cord compression, or clinical imaging manifestations suggesting impending spinal cord compression. 6. Any cardiovascular or cerebrovascular diseases or cardiovascular risk factors that may affect the treatment of the study drug. 7. Poorly controlled diabetes and hypertension. 8. The toxicity of previous anti-tumor treatment before the first administration has not recovered to ≤ 1 grade (evaluated based on NCI-CTCAE v5.0) or has not reached the level specified in the inclusion/exclusion criteria. 9. Had other malignant tumors within 3 years before the first administration. 10. Subjects with severe and/or uncontrolled concomitant diseases. 11. Active hepatitis B or active hepatitis C. 12. Human immunodeficiency virus (HIV) test positive or having a history of acquired immune deficiency syndrome (AIDS); known active syphilis infection. 13. Subjects with a history of radionuclide/radioactive drug allergy, or allergic to any component of the study formulation. 14. During the screening process before the first administration, the condition deteriorated rapidly, such as significant changes in the investigator's assessment of physical condition, etc. 15. Subjects participating in another clinical study, unless it is an observational (non-interventional) clinical study or the follow-up period of an intervention study. 16. Any unstable disease or clinical condition, or any condition that may endanger the safety of the subject or affect the subject's compliance, or any other conditions that the investigator deems inappropriate for participation in this study.