The Selection of Initial Treatment Regimens for Adolescent Nephrotic Syndrome.

Condition(s) studied

Investigational drug(s) / intervention(s)

Renal Biopsy: Renal biopsy is performed to clarify the renal pathology.

Study summary

Given that the treatment strategy for adolescent PNS has a significant impact on growth and development, but there are few cases and a lack of clinical research, this study plans to collaborate with several domestic top-tier children's nephrology centers to conduct a retrospective real-world study of adolescent PNS. The aim is to understand the current diagnosis and treatment status of adolescent PNS and compare the advantages and disadvantages of various therapies, in order to provide a more scientific, rational, and effective treatment plan for adolescent PNS.

Eligibility

Primary outcome measure(s)

• The number of relapses of proteinuria — From the start of treatment to 1 year and 2 years.
  The total number of proteinuria relapses in patients within 2 years of treatment is counted.
• A 50% decline in kidney function — At 6 months, 1 year, and 2 years of treatment.
  Calculate the proportion of patients with a greater than 50% decline in kidney function at 6 months, 1 year, and 2 years of treatment.
• Relapse-free rate of proteinuria after treatment — At 3 months, 6 months, 1 year, and 2 years after treatment initiation.
  The proportion of participants who remain free of proteinuria relapse after initial treatment, assessed by urine analysis and clinical evaluation.
• Incidence of steroid resistance after treatment — At 4 weeks after treatment initiation.
  The proportion of participants who do not achieve remission with standard steroid therapy, assessed clinically and by laboratory evaluation.

Trial sites (1)

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