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Recruiting Observational

Multi-modal Adverse Events Prediction for Premature Coronary Heart Disease Trial: MAP-CHD Trial

NCT07004452 · tracked via the Priya Life Science China tracker
Phase
Observational
Started
2025-03-31
Last updated
2025-06-04

Condition(s) studied

Premature Coronary Heart Disease

Study summary

The goal of this observational cohort study is to establish a risk prediction model for adverse events in Chinese individuals under 45 years old with premature coronary artery disease. The main questions it aims to answer are:

* What are the major risk factors for poor prognosis in Chinese patients with premature coronary artery disease?
* What is the difference in the prognosis of patients with premature coronary heart disease with different phenotypes? Participants taking no mandatory intervention will be followed up for 2 year, with blood tests at 1 year and outpatient or telephone interviews at other timepoints.

Eligibility

Sex
ALL
Min age
18 Years
Max age
45 Years
Healthy volunteers
No
Inclusion Criteria: * Age 18-45 years; * Clinically confirmed CAD with ≥50% luminal stenosis in at least one major coronary artery or significant branch, verified by coronary angiography; * For acute coronary syndrome (ACS) or percutaneous coronary intervention (PCI) patients: clinical stability meeting discharge criteria post-treatment; * Voluntary participation with signed informed consent. Exclusion Criteria: * Heart transplant recipients; * Severe systemic comorbidities with life expectancy \<1 year; * Previous enrollment in other drug/device clinical trials without completing the primary endpoint observation period; * Inability to comply with follow-up (e.g., dementia, severe psychiatric disorders).

Primary outcome measure(s)

  • MACCE, defined as a composite of cardiac death, MI, ischemic stroke, and repeat revascularization — 2 years
  • Sensitivity for 2-year MACCE prediction — 2 years
    For the validation cohort
  • Specificity for 2-year MACCE prediction — 2 years
    For the validation cohort

Trial sites (1)

FacilityCityRegionStatus
FuWai Hospital Beijing China Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07004452 on ClinicalTrials.gov ↗ ← All trials in China