Ireland
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Active, not recruiting Observational

Whole-slide Image and CT Radiomics Based Deep Learning System for Prognostication Prediction in Upper Tract Urothelial Carcinoma

NCT06993779 · tracked via the Priya Life Science China tracker
Phase
Observational
Started
2025-01-01
Last updated
2025-05-29

Condition(s) studied

UTUC

Investigational drug(s) / intervention(s)

Deep learning system for prognostication prediction in upper tract urothelial carcinoma

Deep learning system for prognostication prediction in upper tract urothelial carcinoma: develop and validate a deep learning system for prognostication prediction in upper tract urothelial carcinoma based on CT radiomics and whole slide images.

Study summary

Upper Tract Urothelial Carcinoma (UTUC), characterized by its anatomical complexity and often aggressive clinical behavior, presents substantial difficulties in accurate diagnosis and reliable prognostication. The stratification of postoperative survival utilizing radiomics features derived from imaging and characteristics from whole slide images could prove instrumental in guiding therapeutic decisions to enhance patient outcomes. In this research, our objective is to construct a deep learning-based prognostic-stratification system designed for the automated prediction of overall and cancer-specific survival in individuals diagnosed with UTUC.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patients with Upper Tract Urothelial Carcinoma (UTUC) who had radical nephroureterectomy (RNU). * Contrast-enhanced CT scan (e.g., CT urography) less than two weeks before surgery. * Complete CT image data and clinical data. * Complete whole slide image data. Exclusion Criteria: * Patients with a postoperative diagnosis of non-urothelial carcinoma. * Poor quality of CT images and/or whole slide image data. * Incomplete clinical and follow-up data.

Primary outcome measure(s)

  • Overall survival — up to 10 years
    the time from the date of surgery to death from any cause or the date of last contact (censored observation) at the date of data cut-off.

Trial sites (1)

FacilityCityRegionStatus
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, chongqing, chongqing 400016 Recruiting Chongqing China
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06993779 on ClinicalTrials.gov ↗ ← All trials in China