Human Genes and Microbiota in Early Life

Condition(s) studied

Investigational drug(s) / intervention(s)

No intervention: No intervention

Study summary

The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life and their interaction with the host on maternal-offspring health consequences in later life in the born in Guangzhou cohort study in China. Identification of the effect of microbiota in early life, as well as environmental factors and microbe-host interaction, will lead to a better understanding of disease pathogenesis and provide a foundation for targeted mechanistic investigation into the consequences of microbial-host crosstalk for long-term health. It also can result in new strategies to predict and prevent diseases in later life.

Eligibility

Primary outcome measure(s)

• Numbers of participants with Childhood diseases. Including: — 42 days, 6 months, 1, 3, 6, 8-9, 14, and18 years of age
  Obesity，asthma，allergic diseases，Delayed neural development，type 1 diabetes，maturity-onset diabetes of the young（MODY), hypertension
• Numbers of participants with maternal diseases. Including: — during pregnancy, 42 days, 6 months, 1, 3, 6, 8-9, 14, and18 years after delivery
  Obesity，asthma，allergic diseases，type 1 diabetes，type 2 diabetes, hypertension , cardiovascular diseases，and obstetric complications，including gestational diabetes，pregnancy induced hypertension, ect.

Trial sites (1)

More Guangzhou Women and Children's Medical Center trials in China

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