The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis

Condition(s) studied

Investigational drug(s) / intervention(s)

Shenfu Injection: The treatment will utilize Ginseng and Aconite Injection, which primarily consists of Red Ginseng and Aconite

Study summary

This study focuses on improving heart function in patients with life-threatening blood infections (septic shock). When the body fights severe infections, the heart sometimes struggles to pump blood effectively, which can lead to dangerous complications. Current treatments like intravenous fluids and blood pressure medications have limitations in protecting heart function.

This multicenter clinical trial aims to evaluate whether adding Shenfu Injection - a traditional Chinese medicine preparation widely used to enhance cardiac function in cardiovascular diseases - to standard therapies can:

1. Prevent myocardial dysfunction during septic shock
2. Accelerate cardiac recovery if complications occur
3. Improve overall survival and clinical outcomes The randomized controlled design will compare therapeutic effects between two groups: one receiving standard septic shock treatment alone, and the other receiving standard treatment combined with Shenfu Injection.

Eligibility

Primary outcome measure(s)

• The incidence of septic cardiomyopathy — Day 7
• Duration of vasopressor administration — 28 days
  The duration of vasopressor administration refers to the total time a patient requires vasopressor medications, measured in hours or days, to maintain blood pressure and support circulation.

Trial sites (1)

More First Affiliated Hospital of Wannan Medical College trials in China

Other trials for the same condition