Ireland
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Starting soon Observational

To Observe the Clinical Effect of Femoral Nerve Block With Low Concentration of Ropivacaine Based on DPN Grading

NCT06732362 · tracked via the Priya Life Science China tracker
Sponsor
Zheng Guo
Phase
Observational
Started
2025-08-20
Last updated
2025-08-03

Condition(s) studied

Diabetes Mellitus, Type 2

Investigational drug(s) / intervention(s)

Different DPN ratings

Different DPN ratings: According to the TCSS grading scale, DPN patients were graded into different grades, and the mild and severe groups and the control group were selected to observe the clinical effects between the three groups

Study summary

The purpose of this study was to quantitatively standardize the performance of patients with DPN with different course of disease using high-frequency ultrasound, and to design experiments to verify the conclusion that DPN patients with peripheral nerve damage increased nerve sensitivity to local anesthetic drugs and increased block time, and to achieve the same blocking effect by using low-concentration local anesthetic drugs, so as to reduce the probability of complications such as transient nerve injury, severe nerve injury, and local anesthetic poisoning.

Eligibility

Sex
ALL
Min age
55 Years
Max age
85 Years
Healthy volunteers
Accepted
Inclusion Criteria:All patients met the 1999 WHO diagnostic criteria for diabetes. \- Exclusion Criteria:(1) Type 1 diabetes; (2) Peripheral neuropathy obviously caused by other reasons; (3) Patients with neuropathy caused by diabetic foot ulcers and gangrene, as well as known history of bone and joint trauma or surgery of the lower limbs; (4) Contraindications to peripheral nerve block (such as local anesthetic allergy, coagulation dysfunction, peripheral infection, etc.) (5) Contraindications to drug components of postoperative analgesic pumps; (6) Existing opioid therapy. \-

Primary outcome measure(s)

  • N/OFQ — 24 hours
    Serum N/OFQ levels

Trial sites (1)

FacilityCityRegionStatus
Second Hospital of Shanxi Medical University Taiyuan Shanxi
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06732362 on ClinicalTrials.gov ↗ ← All trials in China