This is an observational study to explore the etiology and clinical classification in patients with obesity and to achieve personalized treatment.
Eligibility
Sex
ALL
Min age
20 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Patients with BMI≥28kg/m2
* Aged 18-65 years of both sexes, right-handed
* At least 6 years of education
* Patients agreed and signed the informed consent
Exclusion Criteria:
* Fewer than 6 years of education
* Left-handedness
* Dementia
* Acute metabolic complications such as diabetic ketoacidosis
* Hyperglycaemic hyperosmolar state and hypoglycaemic coma within the previous 3 months; history or presence of neurological or psychiatric disorders;
* Presence of hypothyroidism;
* History of malignancy, or severe kidney or liver dysfunction.
Primary outcome measure(s)
Brain imaging features in patients with obesity by fMRI — From 2024 to 2028 total brain volume, grey matter volume, white matter volume,cerebrospinal fluid volume, and nuclear bulk volume by MRI-derived normalized measures. All patients underwent odor-induced task fMRI on a 3.0T MR scanner with 222 volumes for task fMRI and 230 volumes for resting-state fMRI.
Biomarkers of patients with obesity by blood sample — From 2024 to 2028 Diagnostic biomarkers, predictive biomarkers, and prognostic biomarker in patients with obesity by blood sample
Clinical classification of patients with obesity — From 2024 to 2028 Based on the exploration of the unique brain imaging and biomarkers in patients with obesity, the clinical classification of obese patients was carried out.
Prevention and intervention strategies for obesity based on clinical classification — From 2024 to 2028 According to the clinical classification of obesity investigated in our previous study, personalized prevention and treatment strategies are designed to effectively slow down or reverse the obesity disease.
Trial sites (1)
Facility
City
Region
Status
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Nanjing
Jiangsu
More The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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