Neoadjuvant Chemoimmunotherapy Followed by Surgery and Postoperative Radioimmunotherapy

Inclusion Criteria: * Ages 18-75; * Radical operation for esophageal cancer; * Esophageal squamous cell carcinoma was confirmed by postoperative pathology; . Preoperative imaging (enhanced cervical, thoracoabdominal CT+ bone scan) and postoperative pathological evaluation were performed, and the stage was pIIB-IVA (AJCC eighth edition staging criteria: T≥3 or N+). * More than or equal to 12 lymph nodes were surgically removed; * Postoperative ECOG score 0-1, able to tolerate postoperative adjuvant radiotherapy and immunotherapy; * Informed consent signed by patient or family member. Exclusion Criteria: * Less than 18 years old, more than 75 years old; * did not receive radical resection of esophageal cancer, including palliative resection; * Postoperative pathology showed non-esophageal squamous cell carcinoma; * After preoperative imaging (enhanced cervical, thoracoabdominal CT+ bone scan) and postoperative pathological evaluation, the stage was pI, IIA, IVB (AJCC eighth edition staging standard); e. Less than 12 lymph nodes were surgically removed; * Postoperative ECOG score 2-3 points, unable to tolerate postoperative adjuvant radiotherapy and immunotherapy; * The patient or family member did not sign the informed consent.