Eligibility
Inclusion Criteria:
* Subjects must meet all the following inclusion criteria:
1. Male or female, ≥40 years and \<75 years of age at Screening.
2. Diagnosis of Idiopathic Parkinson's disease according to the UK Brain Bank.
3. Insufficient control of motor symptoms with an average of ≥2.5 hours of OFF time per day over 3 consecu-tive days despite optimized treatment, as confirmed by the PD patient diary at Screening.
4. Stable Parkinson's symptoms and an optimal regimen of Parkinson's medications for at least 4 weeks prior to screening, with a duration of levodopa treatment of ≥1 year.
5. Hoehn and Yahr Stage 2.5\~4 on "off" state.
6. All men and women of childbearing potential must be willing to use at least one highly effective method of contraception from the signing of informed consent until one year after administration of the study drug.
7. Men must agree not to donate sperm, and women must agree not to donate eggs within at least one year after administration of the study drug.
8. The patient must understand the purpose and risks of the study, sign and date the informed consent, and give authorization to use the protected health information in accordance with national and local privacy regulations.
9. The patient has a reliable study partner/informant (e.g., a family member, friend) willing and able to partici-pate in the study as a source of information on the patient's health status and cognitive and functional abili-ties (including providing input into the rating scales).
Exclusion Criteria:
* Subject has any of the following diseases or disease history
1. Atypical or secondary parkinsonism, including but not limited to symptoms believed to be due to trauma, brain tumor, infection, cerebrovascular disease, or other neurological disease, or to drugs, chemicals, or tox-ins, as determined by the Investigator.
2. Known pathogenic gene mutations of GBA1, PINK1, and Parkin
3. MoCA score ≤16
4. Currently active infection or a severe infection (e.g., pneumonia, septicemia, central nervous system infec-tions \[e.g. meningitis, encephalitis\]) within 12 weeks prior to Screening
5. Active infection of HBV, HCV or TP, or with HIV-positive at screening.
6. Unstable autoimmune disease within 6 months prior to Screening, or requiring chronic immunosuppression.
7. Poorly controlled diabetes (Screening glycosylated hemoglobin \[HbA1C\] ≥ 7%), or uncontrolled hyperten-sion.
8. History of stroke or transient ischemic attack, unstable angina, myocardial infarction, chronic heart failure (New York Heart Association Class III or IV), or clinically significant conduction abnormalities (e.g., un-stable atrial fibrillation) within 1 year prior to Screening.
9. New or unstable psychiatric conditions (e.g. psychosis, severe depression, or with current suicidal ideation or suicide attempt) within 1 year of screening.
10. History of malignancy within 3 years of screening, other than fully excised non-melanoma skin cancers, non-metastatic prostate cancer, and fully treated carcinoma in situ, provided it has been stable for at least 6 months.
11. Any medical conditions that, in the opinion of the Investigator, could interfere with study-related proce-dures (including the safe performance of intraparenchymal injection), such as severe dyskinesia/impulse control disorders/tremor that may interfere with drug injection, brain implants, bleeding diathesis, clinically significant coagulopathy, thrombocytopenia, or increased intracranial pressure.
Subject who is receiving or has a history of any of the following medications
12. Any type of prior gene or cell therapy.
13. Prior brain surgery for deep brain stimulation, focused ultrasound, infusion therapies or any other brain sur-gery for PD, or planned brain surgery for PD within 1 year after study entering.
14. Any anticoagulant or antiplatelet therapies that could not be stopped before study drug injection.
15. Any live vaccine within 4 weeks prior to Screening. Subject who meets any of the following test endpoints at screening
16. An MRI showed a significant structural abnormality or lesion, bleeding, or \>1 cm3 infarct, which, in the opinion of the Investigator, are contraindications to intraparenchymal injection.
17. Clinically significant abnormalities in laboratory test values at Screening are in the opinion of the Investiga-tor, unsuitable for enrollment immediately.
Subject under any of the following general conditions
18. Contraindications to MRI/PET and/or agents used in PET.
19. Contraindications to general anesthesia or deep sedation.
20. Woman who is pregnant or breastfeeding.
21. Participation within 3 months prior to Screening in another therapeutic investigational drug or device study, unless it can be documented that the patient received a placebo.
22. Presence of substance (drug, alcohol) abuse within 2 years prior to Screening.
23. The patient is generally frail or has any condition for which, in view of the Investigator, participation in the study would not be in the best interest of the patient or is likely to prohibit further participation during the study.