Washed Microbiota Transplantation for Malnutrition

Condition(s) studied

Investigational drug(s) / intervention(s)

washed microbiota transplantation: The prepared microbiota suspension was infused into the patients' gut.

Study summary

Malnutrition is a pathological condition in which dietary intake fails to meet the body's energetic or nutritional needs. It may be caused by macronutrient or micronutrient deficiencies, high energy expenditure, impaired nutrient absorption or assimilation. Malnutrition can affect all stages of life. In adults, malnutrition is strongly associated with poor clinical outcomes such as increased morbidity, increased mortality and prolonged hospitalization. In children, malnutrition can lead to growth retardation, cognitive impairment and immune dysfunction.

Eligibility

Primary outcome measure(s)

• change of the third lumbar vertebrae skeletal muscle mass and height — baseline, 12 weeks post transplantation
  The third lumbar vertebrae skeletal muscle mass represents the sum of the cross-sectional areas of the skeletal muscles at the L3 level, including the psoas major, the erector spinae, the quadratus lumborum, the musculus transversus abdominis, the obliquus externus abdominis and the obliquus internus abdominis. Skeletal muscle mass and height will be combined to report the third lumbar vertebrae skeletal muscle mass index(L3 SMI) in cm\^2/m\^2.
• change of weight and height — baseline, 4 weeks, 8 weeks, 12 weeks post transplantation
  Weight and height will be combined to report BMI in kg/m\^2.

Trial sites (1)

More The Second Hospital of Nanjing Medical University trials in China

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