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Clinical Trials in China / NCT06443125
Recruiting Not applicable

Study on Therapeutic Mechanism of Natural Psychotherapy for Neurosis

NCT06443125 · tracked via the Priya Life Science China tracker
Sponsor
Xiang Yang Zhang
Phase
Not applicable
Started
2023-08-01
Last updated
2024-12-27

Condition(s) studied

Obsessive-Compulsive Disorder

Investigational drug(s) / intervention(s)

Natural psychotherapy

Natural psychotherapy: Draw ideas from traditional Chinese culture, learn from the practice of Morita therapy in Japan, and create local practice experience. At the same time, a variety of research methods such as cognitive assessment and brain imaging were used to establish the scientific, professional and objective evaluation indexes of the therapy.

Study summary

explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder

Eligibility

Sex
ALL
Min age
15 Years
Max age
60 Years
Healthy volunteers
No
Inclusion Criteria: * Have a diagnosis of obsessive-compulsive disorder or compulsive behavior * Duration of symptoms for not less than 12 months * Age 15-60 years old. * You can participate in the whole experiment and offline assessment in Beijing Exclusion Criteria: * Documented disease of physical diseases including, but not limited to stroke, tumor, Parkinson's disease, Huntington's disease, seizure, epilepsy, history of brain trauma * Subjects who suffered from alcohol or illegal drug abuse/dependence

Primary outcome measure(s)

  • Obsessive-compulsive symptoms — Baseline, 12 weeks
    Obsessive-compulsive symptoms were assessed according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), The total score ranges from 0 to 40, with higher scores indicating more severe symptoms.
  • Cognitive function — Baseline, 12 weeks
    Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability.
  • Mood and behavior — Baseline, 12 weeks
    Mood changes judged using gait and face recognition
  • ERP components associated with cognitive function — Baseline, 12 weeks
    To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis
  • rest fMRI in Obsessive-compulsive patients — Baseline, 12 weeks
    The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity：FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences.
  • Behavioral inhibition — Baseline, 12 weeks
    behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability.

Trial sites (2)

FacilityCityRegionStatus
Anhui Mental Health Center Hefei Anhui Recruiting
Institute of Psychology, Chinese Academy of Sciences Beijing China Recruiting

Other trials for the same condition

The Effect of Immersive Virtual Reality Treatment With Cognitive Behaviour Therapy for Obsessive-Compulsive Disorder Starting soon
Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD Recruiting
Identifying Local Field Potential Biomarkers for Obsessive-compulsive Disorder Treatment With Deep Brain Stimulation Recruiting
Digital Mindfulness-Based Therapy for Obsessive-Compulsive Disorder Recruiting
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06443125 on ClinicalTrials.gov ↗ ← All trials in China