Study on the Mechanism of ZhenQiFuZheng in the Treatment of Allergic Rhinitis Based on Intestinal Flora and Metabolites

Condition(s) studied

Investigational drug(s) / intervention(s)

ZhenQi FuZheng granules (ShiDaiYangGuang): 1 bag at a time, twice a day. Oral orally for 4 weeks.

Study summary

ZhenQi FuZheng granules has been used to improve the immune function of human body, protect the bone marrow and adrenal cortex function and promote the recovery of positive function in traditional Chinese medicine care, especially with the immune imbalance diseases like post-surgery, chemotherapy and rhinitis. This project intends to establish AR（allergic rhinitis）specimen library, cell and animal model experiment, combining clinical cohort research with applied basic research, further assess the therapeutic mechanism of ZhenQiFuZheng granules in AR. We assume that ZhenQi FuZheng granules could cause the metabolic omics changes of nasal inflammatory factors and nasal secretions in AR patients, thus improving the type 2 inflammation level of allergic rhinitis.

Eligibility

Primary outcome measure(s)

• Rhinoconjunctivitis Quality of Life Questionnaire — 12 weeks
  Patients were scored by questionnaire before and after treatment, and the change in score before and after treatment was the primary outcome measure
• Visual Analog Score for pain — 12 weeks
  Patients were scored by questionnaire before and after treatment, and the change in score before and after treatment was the primary outcome measure

Trial sites (1)

More The First Affiliated Hospital with Nanjing Medical University trials in China

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