The Impact of Smoking on the Prognosis of Elderly Surgical Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

none intervention: No interventions are administered to either group of patients.

Study summary

Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative cognitive dysfunction and even mortality. However, the underlying mechanisms of its onset are not yet fully understood. Evidence suggests that smoking can lead to gut microbiota dysbiosis and metabolic dysfunction, and the gut microbiota and its metabolites play a crucial role in cognitive function through the gut-brain axis. Yet, no studies have reported whether smoking could affect the occurrence of postoperative delirium and the quality of postoperative recovery through the gut microbiota. This study aims to observe the incidence of postoperative delirium and the postoperative recovery quality scores between smokers and non-smokers.

Eligibility

Primary outcome measure(s)

• Postoperative delirium — Within 3 days post-surgery
  CAM method
• Quality of recovery in the first postoperative day — Up to 24 hours after surgery.
  Quality of recovery is assessed with the Quality of Recovery-15 questionaire in the first postoperative day.

Trial sites (1)

More Affiliated Hospital of Nantong University trials in China

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