Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction

NCT06368544 · tracked via the Priya Life Science China tracker

Sponsor

Peking University Third Hospital

Phase

Not applicable

Started

2024-07-22

Last updated

2025-07-25

Condition(s) studied

Anterior Cruciate Ligament InjuriesCartilage Degeneration

Investigational drug(s) / intervention(s)

lower-body positive-pressure

lower-body positive-pressure: By increasing the chamber in the lower body around Pressure acts as a counterweight to gravity

Study summary

A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical characteristics of cartilage and the biomechanical risk index were proposed to providing exercise guidance and training for ACLR people and it is suggested that it can prevent and reduce the risk of cartilage degeneration early after operation.

Eligibility

Sex

ALL

Min age

18 Years

Max age

40 Years

Healthy volunteers

Inclusion Criteria: 1. Patients with ACL rupture were diagnosed by MRI; 2. Unilateral ACL rupture for the first time should be performed in our hospital (Department of Sports Medicine, Peking University Third Hospital)The art of reconstruction; 3. Normal BMI range: 18.5-23.9 kg/m2; 4. Within 6 months from the trauma; 5. The affected knee joint has passed the acute stage, no obvious redness, pain,inflammation, and limited joint motion,basically restore joint motion. Exclusion Criteria: 1. BMI\<18.5 kg/m2 or BMI≥24 kg/m2); 2. There is a history of contralateral lower limb musculoskeletal system injury and surgery; 3. ACL injury time \> 6 months; 4. Outerbridge damage rating Ⅲ and Ⅳ; 5. Patients with meniscal tears who are expected to undergo meniscal suture surgery at the time of ACLR surgery; 6. Serious injury to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament; 7. There is metabolic syndrome (obesity, dyslipidemia, diabetes, etc.), which will involve articular cartilage Epidemic diseases, serious cardiovascular and cerebrovascular diseases, etc.; 8. Those who do not want to accept this treatment

Primary outcome measure(s)

Gait biomechanical data — from 3 months to 2 years
Hip, knee and ankle joint angles and moments at the moment of landing and peak ground reaction force.
Gait biomechanical data — from 3 months to 2 years
The maximum three-dimensional torque of the hip, knee and ankle during the support phase.
Gait biomechanical data — from 3 months to 2 years
The maximum three-dimensional Angle and range of motion of the hip, knee and ankle joints during the whole gait cycle.
Gait biomechanical data — from 3 months to 2 years
The symmetry index of Angle and torque of each joint.
Gait biomechanical data — from 3 months to 2 years
The two groups of joint biomechanics and their gait touch information characteristics
Biochemical characteristics of knee cartilage — from 3 months to 2 years
T1rho values of different regions of knee cartilage
Biochemical characteristics of knee cartilage — from 3 months to 2 years
T2 mapping values of different regions of knee cartilage

Trial sites (1)

Facility	City	Region	Status
Peking University Third Hospital	Beijing	China	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06368544 on ClinicalTrials.gov ↗ ← All trials in China