Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure

Inclusion Criteria: 1. Age ≥18 years 2. Willingness and ability to give written informed consent 3. Nuclide-myocardial metabolic perfusion imaging or Magnetic Resonance Imaging (MRI) revealed infarcted myocardium in the left anterior descending branch (LAD) coronary artery supply area 4. LVEF\<50% as assessed by Echocardiography or LVEF≤40% as assessed by MRI 5. Patients have indications for Coronary Artery Bypass Grafting Exclusion Criteria: 1. Presence of a pacemaker, implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy device (CRT) 2. Diagnosed with malignancy within 5 years 3. Autoimmune disease 4. Recipients of organ transplant. 5. Patients undergoing other surgical operations (excluding resection of ventricular aneurysm and left atrial appendage excision/occlusion). 6. Severe ventricular arrhythmia 7. Contraindication to CABG surgery 8. Contraindication to cardiac MRI or PET/CT scan. 9. Contraindication to immunosuppressants 10. Participation in another clinical trial within 3 months prior to screening 11. Pregnancy, lactation, or a positive serum pregnancy test 12. Any other condition considered by the investigator to be inappropriate for inclusion in this clinical trial