Autologous Tumor Infiltrating Lymphocytes (GT101 Injection) in Patients With Recurrent or Metastatic Cervical Cancer
Condition(s) studied
Investigational drug(s) / intervention(s)
GT101: Infusion
Gemcitabine injection: Injection
IL-2: Injection
Study summary
This is a Phase II, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of Autologous Tumor Infiltrating Lymphocytes (GT101 injection) compared with Gemcitabine in participants with recurrent or metastatic cervical cancer.
Eligibility
Primary outcome measure(s)
- Progression Free Survival (PFS) (per RECIST V.1.1) by IRC assessment — Up to 2 years post infusion
Defined as time from first study treatment until disease progression per Response Evaluation Criteria in Solid Tumors \[RECIST Version 1.1\] as assessed by the Independent Review Committee (IRC) or death from any cause, whichever occurs first.
Trial sites (38)
| Facility | City | Region | Status |
|---|---|---|---|
| Beijing Obstetrics and Gynecology Hospital, Capital Medical University | Beijing | Beijing Municipality | Recruiting |
| Peking University Third Hospital | Beijing | Beijing Municipality | Recruiting |
| The Fifth Medical Center of the General Hospital of the People's Liberation Army of China | Beijing | Beijing Municipality | Not Yet Recruiting |
| Army Medical Center of PLA | Chongqing | Chongqing Municipality | Recruiting |
| Fujian Cancer Hospital | Fuzhou | Fujian | Recruiting |
| Gansu Provincial Cancer Hospital | Lanzhou | Gansu | Recruiting |
| Gansu Provincial Maternity and Child-care Hospital | Lanzhou | Gansu | Recruiting |
| Sun Yat-sen University Cancer Center | Guangzhou | Guangdong | Recruiting |
| Chinese Academy of Medical Sciences Cancer Hospital Shenzhen Hospital | Shenzhen | Guangdong | Recruiting |
| Guangxi Medical University Affiliated Cancer Hospital | Guilin | Guangxi | Recruiting |
| Harbin Medical University Affiliated Cancer Hospital | Ha’erbin | Heilongjjiang | Recruiting |
| The First Affiliated Hospital of Henan University of Science and Technology | Luoyang | Henan | Recruiting |
| Henan Cancer Hospital | Zhengzhou | Henan | Recruiting |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Wuhan | Hubei | Recruiting |
| Zhongnan Hospital of Wuhan University | Wuhan | Hubei | Recruiting |
| Hubei Cancer Hospital | Wuhan | Hubei | Not Yet Recruiting |
| Xiangya Second Hospital of Central South University | Changsha | Hunan | Not Yet Recruiting |
| Hunan Cancer Hospital | Changsha | Hunan | Recruiting |
| Southeast University Affiliated Zhongda Hospital | Nanjing | Jiangsu | Not Yet Recruiting |
| Jiangxi Maternal and Child Health Hospital | Nanchang | Jiangxi | Recruiting |
| The First Affiliated Hospital of Nanchang University | Nanchang | Jiangxi | Recruiting |
| Affiliated Zhongshan Hospital Dalian University | Dalian | Liaoning | Recruiting |
| Dalian Medical University First Affiliated Hospital | Dalian | Liaoning | Not Yet Recruiting |
| Shengjing Hospital of China Medical University | Shenyang | Liaoning | Recruiting |
| Liaoning Cancer Hospital | Shenyang | Liaoning | Recruiting |
| Qilu Hospital of Shandong University | Jinan | Shandong | Recruiting |
| Shandong First Medical University Affiliated Cancer Hospital | Jinan | Shandong | Not Yet Recruiting |
| Jining First People's Hospital | Jining | Shandong | Not Yet Recruiting |
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai Municipality | Recruiting |
| Fudan University Affiliated Obstetrics and Gynecology Hospital | Shanghai | Shanghai Municipality | Recruiting |
| Shanxi Cancer Hospital | Taiyuan | Shanxi | Recruiting |
| The First Affiliated Hospital of Xi'an Jiaotong University | Xi’an | Shanxi | Recruiting |
| West China Hospital, Sichuan University | Chengdu | Sichuan | Recruiting |
| Sichuan University West China Second Hospital | Chengdu | Sichuan | Recruiting |
| Yibin Second People's Hospital | Yibin | Sichuan | Recruiting |
| Tianjin Cancer Hospital | Tianjin | Tianjin Municipality | Recruiting |
| Yunnan Cancer Hospital | Kunming | Yunnan | Recruiting |
| Zhejiang Cancer Hospital | Hangzhou | Zhejiang | Recruiting |
More Grit Biotechnology trials in China
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06241781 on ClinicalTrials.gov ↗ ← All trials in China