3D-MRE and 2D-MRE for Assessing Cirrhosis and Portal Hypertension

Condition(s) studied

Investigational drug(s) / intervention(s)

3D-MRE: All imaging studies were performed by using a 3.0-T MRI system (Signa HDx, GE Healthcare) with an eight-channel phasedarray body coil.

HVPG: HVPG measurements are performed by well-trained interventional radiologists in accordance with standard operating procedures

2D-MRE: All imaging studies were performed by using a 3.0-T MRI system (Signa HDx, GE Healthcare) with an eight-channel phasedarray body coil.

HVPG: HVPG measurements are performed by well-trained interventional radiologists in accordance with standard operating procedures

Study summary

How to construct a novel, non-invasive, accurate, and convenient method to achieve prediction of hepatic venous pressure gradient (HVPG) is an important general problem in the management of portal hypertension in cirrhosis. We plan to compare the ability of three demensional-magnetic resonance elastography (3D-MRE) to two demensional-magnetic resonance elastography (2D-MRE) to establish a risk stratification system and perform tailored management for portal hypertension in cirrhosis.

Eligibility

Primary outcome measure(s)

• Accuracy of the features of 3D-MRE and 2D-MRE for assessing portal hypertension in cirrhosis. — 12 months
  WIth HVPG as reference standand, the overall diagnostic perforemace (accuracy) for cirrhosis and portal hypertension of 3D-MRE and 2D-MRE was compared.

Trial sites (1)

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