The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia

Condition(s) studied

Investigational drug(s) / intervention(s)

H2S content: H2S content

Study summary

The goal of this clinical trial is to learn about in health conditions. The main questions it aims to answer are:

* The pathological significance of GPER in uterine artery dilation in preeclampsia
* The Mechanism of GPER Hippo Pathway Regulating CBS/H2S in Human Uterine Artery Smooth Muscle Cells (hUASMC) This project intends to use GPER interfering RNA, YAP1 interfering RNA, in vivo perfusion experiments of human uterine artery tissue, and single cell patch clamp technology to study hypotheses under physiological/pathological pregnancy conditions at the tissue, cellular, and molecular levels, revealing a novel signal transduction pathway of estrogen stimulating vasodilation, providing new ideas for studying the mechanism of uterine artery blood flow regulation. This research result will provide new targets for intervention and treatment of diseases such as fetal intrauterine growth retardation and preeclampsia.

Eligibility

Primary outcome measure(s)

• H2S content in uterine arterial smooth muscle circulation — 8:00 am
  H2S content in circulation

Trial sites (1)

Other trials for the same condition