Placebo: 3 capsules at a time, three times a day, duration: 12 weeks
Study summary
The purpose of this study is:
1. To evaluate the efficacy of Songling Xuemaikang Capsules(SLXMKC) with grade 1 hypertension.
2. To reveal the potiential effects of SLXMKC on vascular function and structure of patients with grade 1 hypertension.
3. To explore the underlying mechanisms of the therapeutic effects of SLXMKC on the intervention of grade 1 hypertension.
Eligibility
Sex
ALL
Min age
35 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Age between 35-65 years old, male or female;
* Grade 1 essential hypertension;
* Taking no antihypertensive drugs or taking antihypertensive drugs irregularly in the past ;
* Sign the informed consent;
Exclusion Criteria:
* Significant liver and kidney dysfunction, ALT and AST upper the twice of normal range, Scr≥2.0mg/dl, eGFR\<60ml/(min·1. 73m2);
* Gastrointestinal diseases, which may affect drug absorption;
* Be allergic to the clinical trial medicine;
* Pregnant or breastfeeding women, men who plan to give birth within half a year;
* Combined with other serious primary diseases or malignant tumors;
* Hyperlipidemia with or without taking lipid-lowering drugs;
* Combined with left ventricular hypertrophy, ABI \< 0.9, CIMT ≥ 0.9mm or atherosclerotic plaque;
* Hypertensive comorbidities (cerebrovascular disease, other cardiovascular diseases, renal disease, peripheral artery disease, retinopathy, diabetes);
* Other serious conditions in which is not fit for the study.
Primary outcome measure(s)
Change from Baseline in the Mean 24h Systolic Blood Pressure at 4,12 weeks — Baseline and Week 4,12 Change=(Week 12 value- Baseline value) and (Week 4 value- Baseline value)
Trial sites (5)
Facility
City
Region
Status
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Beijing
Beijing Municipality
Recruiting
Suzhou Hosptial of Traditional Chinese Medicine
Suzhou
Jiangsu
Not Yet Recruiting
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Jinan
Shandong
Not Yet Recruiting
China Academy of Chinese Medical Sciences Xiyuan Hospital Jining Hospital
Jining
Shandong
Not Yet Recruiting
China Academy of Chinese Medical Sciences Xiyuan Hospital Shanxi Hospital
Taiyuan
Shanxi
Not Yet Recruiting
More Xiyuan Hospital of China Academy of Chinese Medical Sciences trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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