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Clinical Trials in China / NCT05768399
Recruiting Observational

The Role of Biomarkers in the Occurrence and Development of Asthma

NCT05768399 · tracked via the Priya Life Science China tracker
Sponsor
Children's Hospital of Chongqing Medical University
Phase
Observational
Started
2023-07-04
Last updated
2023-07-07

Condition(s) studied

Asthma in Children

Investigational drug(s) / intervention(s)

The level of biomarkers in Peripheral blood

The level of biomarkers in Peripheral blood: All participants will be extracted 5ml peripheral blood into the anticoagulant tube by nurses and the peripheral blood will be detected for biomarkers of asthma. Children with asthma will take pulmonary function, blood test and specific IgE test etc. The lung function test will be performed by professional technicians and the results will be interpreted by specialists. The blood test and specific IgE test will be collected by specialist nurses and the results will be issued by professional inspectors. Children with asthma and their guardians will be asked for filling the questionnaire of Childhood Asthma Control Test (C-ACT). And then the doctor will check and calculate the scores after completion.

Study summary

To study the expression level of biomarkers such as GITRL in peripheral blood of children with asthma and analyze their correlation with the severity of asthma. To study the predictive value of biomarkers level for the occurrence and development of asthma. And to provide supplementary detection means and predictive indicators for the diagnosis of asthma and the severity of asthma.

Eligibility

Sex
ALL
Min age
4 Years
Max age
12 Years
Healthy volunteers
Accepted
Inclusion Criteria: * In line with the diagnostic criteria in the Guidelines for the Diagnosis and Prevention of Bronchial Asthma in Children (2016 Edition) * Age: 4-12 years old for new diagnosis or recurrent episodes * Typical clinical manifestations and complete clinical data * Family members or guardians of children with informed research and signed consent * All healthy control subjects had no history of lung disease, allergic rhinitis or any other atopic disease Exclusion Criteria: * Suffering from other respiratory diseases (such as bronchiectasis, allergic rhinitis, respiratory failure, tuberculosis, obstructive airway disease) or other inflammatory diseases. * Abnormal development of congenital airway and lung tissue * History of immunosuppressant or glucocorticoid use in the first 4 weeks * Suffering from other endocrine system and immune system diseases * Incomplete clinical data or examinations.

Primary outcome measure(s)

  • The level of biomarkers — 2years
    All participants will be extracted 5ml peripheral blood into the anticoagulant tube by nurses and the peripheral blood will be detected for biomarkers of asthma using RT-qPCR、 ELISA、 Flow cytometry and other methods.

Trial sites (1)

FacilityCityRegionStatus
Shaoqing Zhang Chongqing Chongqing Municipality Recruiting

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Other trials for the same condition

Association Between Genetic Polymorphisms and Type 2 Asthma in Children Recruiting
The Effectiveness and Safety of Dupilumab in Children with Asthma in China: a Real-world Study Enrolling by invitation
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05768399 on ClinicalTrials.gov ↗ ← All trials in China