ICAS - Intracranial AtherosclerosisCerebral Small Vessel Diseases
Investigational drug(s) / intervention(s)
Magnetic resonance imaging
Magnetic resonance imaging: Imaging diagnostics mainly based on Magnetic resonance imaging.
Study summary
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
Eligibility
Sex
ALL
Min age
30 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Age ≥ 18 years
* At least one intracranial artery ≥ 50% atherosclerotic stenosis
* Modified Rankin Scale \< 2
* Mini-mental State Examination \> 24
Exclusion Criteria:
* Concurrent ipsilateral extracranial artery ≥ 50% stenosis
* Pregnant women
* Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)
Primary outcome measure(s)
Progression in total cerebral small vessel disease burden — 1-3 YEARS Total cerebral small vessel disease burden is assessed according to a sum of scores of white matter hyperintensity, cerebral microbleeds, lacunes and enlarged perivasular spaces on magnetic resonance imaging sequences.
Frequency of stroke recurrence — 1-3 YEARS The percentage of symptomatic participants who suffer from stroke recurrence after enrollment in the territory of the targeted stenotic vessel.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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