Clinical Trials in China / NCT05600634
Recruiting
Observational
Multi Center Observation of Sentinel Skin Graft for Detecting Acute Rejection After Renal Transplantation
NCT05600634 · tracked via the Priya Life Science China tracker
Condition(s) studied
Kidney Transplant RejectionSkin Graft
Investigational drug(s) / intervention(s)
Skin allotransplantation
Skin allotransplantation: Sentinel skin grafts from the same donor source will be carried on in the meantime of kidney transplantation for assisting to detect acute renal rejection.
Study summary
The purpose of this study was to explore the accuracy of sentinel skin grafts from the same donor source in diagnosing renal allograft rejection, and to provide new ideas and options for the later clinical diagnosis of renal allograft rejection. Further, try to provide timing guidance for early immunization intervention.
Eligibility
Inclusion Criteria:
1. Patients with end-stage renal disease undergoing renal transplantation;
2. 18-60 years old;
3. Postoperative follow-up points are complete (visit the hospital every week in the first month after surgery, every two weeks in 2-3 months, every four to six months, and every three months in 7-12 months. Follow up at any time when skin rejection is observed. The follow-up time may be adjusted when the condition changes);
4. The participants had good compliance, volunteered to participate in the test and signed the informed consent form.
Exclusion Criteria:
1. Untreated or disseminated malignant tumor;
2. Active period of infectious diseases;
3. Serious cardiovascular disease occurred recently;
4. Combined with other important organ failure;
5. History of mental illness or cognitive impairment;
Primary outcome measure(s)
- 2017 Banff Kidney Transplantation Rejection Rating — Through study completion, an average of 1 year
A rating evaluation on kidney rejection - 2007-edition Banff skin containing allogeneic composite histopathological diagnosis grading — Through study completion, an average of 1 year
Skin histopathological diagnosis - Renal function testing — Through study completion, an average of 1 year
Blood Cr and Bun testing
Trial sites (3)
| Facility | City | Region | Status |
|---|---|---|---|
| Xijing Hospital, Ari Force Medical University | Xi'an | Shannxi | Recruiting |
| First Affiliated Hospital, School of Medicine, Zhejiang University | Hangzhou | Zhejiang | Recruiting |
| Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University | Hangzhou | Zhejiang | Recruiting |
More Second Affiliated Hospital, Zhejiang University, School of Medicine trials in China
Other trials for the same condition
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05600634 on ClinicalTrials.gov ↗ ← All trials in China