No intervention will be applied.: This is an observational study.
Study summary
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
Eligibility
Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Age from 18 to 90 years old;
2. Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured;
3. Without contraindications of CT and MR scan;
4. Can cooperate with the measurement of the medical history, physiological indicators and brain imaging.
Exclusion Criteria:
1. Known clinical history with congenital or acquired organic diseases (such as aortic stenosis);
2. Known history of drug abuse;
3. Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia).
Primary outcome measure(s)
White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging) — every two years up to 30 years
microbleeds of the brain measured by MRI (magnetic resonance imaging) — every two years up to 30 years
Lacunes of the brain measured by MRI (magnetic resonance imaging) — every two years up to 30 years
Cerebral blood flow measured by MRI (magnetic resonance imaging) — every two years up to 30 years
Brain volume measured by MRI (magnetic resonance imaging) — every two years up to 30 years
White matter microstructural integrity of the brain measured by MRI (magnetic resonance imaging) — every two years up to 30 years
Trial sites (2)
Facility
City
Region
Status
Beijing Friendship Hospital, Capital Medical University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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