EyeConic: Qualification for Cone-Optogenetics

NCT05294978 · tracked via the Priya Life Science China tracker

Sponsor

Institute of Molecular and Clinical Ophthalmology Basel

Phase

Observational

Started

2021-07-01

Last updated

2025-07-31

Condition(s) studied

Retinal Dystrophies

Investigational drug(s) / intervention(s)

Optical coherence tomography (OCT)

Optical coherence tomography (OCT): Data of macular optical coherence tomography (OCT)

Study summary

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria (patients): * Diagnosis of generalized IRD * Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye * Availability of macular optical coherence tomography (OCT) Inclusion Criteria (controls): * Normal ophthalmic findings * Availability of macular optical coherence tomography (OCT) Exclusion Criteria (all): * Other eye diseases with a significant effect on vision or retinal structure * Extraocular disease affecting retinal structure such as neurodegenerative diseases

Primary outcome measure(s)

OCT - Central retinal volume — Baseline (about 10 minutes)
Number of participants with preserved central retinal volume

Trial sites (9)

Facility	City	Region	Status
University of California San Francisco, Department of Ophthalmology	San Francisco	California	Recruiting
Bascom Palmer Eye Institute	Miami	Florida	Recruiting
University of Pittsburgh, Department of Ophthalmology	Pittsburgh	Pennsylvania	Recruiting
Beijing Institute of Ophthalmology	Beijing	China	Recruiting
Universitätsklinikum Tübingen Augenklinik	Tübingen	Germany	Recruiting
Semmelweis University, Department of Ophthalmology	Budapest	Hungary	Recruiting
Oculista Ospedale Parma	Parma	Italy	Recruiting
University Hospital Basel, Eye Clinic	Basel	Switzerland	Recruiting
Moorfields Eye Hospital	London	United Kingdom	Recruiting

Other trials for the same condition

Natural History Study of Inherited Retinal Diseases Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05294978 on ClinicalTrials.gov ↗ ← All trials in China