Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

Condition(s) studied

Study summary

The inflammatory storm in critically ill patients releases cytokines, causing systemic immune damage, which may be an important cause of multiple organ failure and even death. Inflammatory storms exacerbate the deterioration of the disease in those children. Gamma globulin may be an effective option to control inflammatory storms. However, this preliminary result needs to be verified from reliable and representative RCTs. In our study, we conducted a retrospective study on the use of gamma globulin and an unused control group. At present, the indications of IVIG are mainly focused on the neuromuscular system and the blood system. We hope to establish a more appropriate and operable evaluation table for the suitability of gamma globulin for clinical use.

Eligibility

Primary outcome measure(s)

• The death rate of children — within 28 days after they discharged from PICU
  The death rate of children in 28 days after their discharged from PICU
• length of stay in PICU — up to 28 days
  Time from PICU admission to discharge

Trial sites (2)

More Children's Hospital of Fudan University trials in China

Other trials for the same condition