Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging

NCT04602338 · tracked via the Priya Life Science China tracker

Sponsor

Chinese Academy of Medical Sciences, Fuwai Hospital

Phase

Observational

Started

2020-11-01

Last updated

2022-04-18

Condition(s) studied

Heart Failure, DiastolicMulticenter Study

Study summary

The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are not well understood. It is difficult to recognize the subclinical changes of the cardiac in the early stage with conventional imaging techniques, and it is common to ignore the existence of the clinical alterations. This study aimed to investigate the cardiac features, early diagnosis and risk factors of HFpEF patients, based on the multi-modality (Magnetic resonance imaging- nuclear medicine imaging- echocardiography) imaging and multicenter study, combined with large data and artificial intelligence. This study will provide deep insights into the HFpEF in multicenter population.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: * left ventricular ejection fraction (LVEF)≥50%； * N-terminal pro-b type natriuretic peptide (NT-proBNP)\>220pg/ml or b type natriuretic peptide (BNP) \>80 pg/ml; * symptoms and syndromes of heart failure; * At least one criteria of cardiac structure (left ventricular hypertrophy, or left atrial enlargement) and function abnormalities (based on tissue doppler, color doppler). Exclusion Criteria: * Special types of cardiomyopathy, including hypertrophic cardiomyopathy, restricted cardiomyopathy, etc. * Infarction, myocardial fibrosis caused by ischemic cardiomyopathy and acute coronary syndrome ; * Severe arrhythmia; * Severe primary cardiac valvular disease; * Restrictive pericardial disease; * Refuse to participate in the study.

Primary outcome measure(s)

All-cause Death — 1-8 year
the incidence of all-cause death
Cardiovascular Death — 1-8 year
the incidence of cadridovascular death
Hospitalization Due to Heart Failure — 1-8 year
the incidence of Hospitalization Due to Heart Failure

Trial sites (1)

Facility	City	Region	Status
Fuwai Hospital	Beijing	Beijing Municipality	Recruiting

More Chinese Academy of Medical Sciences, Fuwai Hospital trials in China

Transaxillary TAVR With Solely Echocardiography Guidance Recruiting

Covered vs Bare Metal Stents for Atherosclerotic Renal Artery Stenosis Starting soon

CMR Prognostic Markers in Ischemic Heart Disease Recruiting

STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for Oral Anticoagulant Recruiting

CHina Adrenal Venous saMPling InvestigatiON Recruiting

Other trials for the same condition

Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF Recruiting

Multi-Omics Inflammatory Phenotype for ABPA Recurrence Risk Prediction Recruiting

Multicenter Clinical Trial on the Effectiveness and Safety of Instillation of BCG and Alternative BCG Protocols for Intermediate and High-risk Non-muscle Invasive Bladder Cancer Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04602338 on ClinicalTrials.gov ↗ ← All trials in China