Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS)

Condition(s) studied

Investigational drug(s) / intervention(s)

Amyotrophic lateral sclerosis: AMYOTROPHIC lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the cortex, brainstem and spinal cord1,2. Its cause is unknown and it is uniformly fatal, typically within five years3

Study summary

1. Describe the distribution of ALS in mainland China, to explore the differences in the number of ALS in different times, regions and populations in order to further explore the causes affecting the distribution of ALS;
2. To investigate the cause of ALS in mainland China in the crowd disease development process and the corresponding characteristics change ;
3. To explore the effect of prognosis of ALS;

Eligibility

Primary outcome measure(s)

• Overall Survival — 5 years to 10 years after recruitment
  Time interval from disease diagnosis to death
• Indicators of disease progression — 1 year to 10 years after recruitment
  1\) in the diagnosis of disease progression (⊿ FS) = (diagnosis of FRS - R score - when follow-up FRS - R)/diagnosis and follow-up time 2）Weight loss =(weight at diagnosis - weight at follow-up)/time to follow-up 3) BMI decreased = (BMI) at the time of diagnosis of BMI - follow-up/diagnosis and follow-up time 4) FVC decreased = (FVC - during the diagnosis to follow-up FVC)/diagnosis and follow-up time 5) between the above indexes can also be in all follow-up multiple numerical calculation, observing the trend of the change over time

Trial sites (1)

More Peking University Third Hospital trials in China

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