Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever

Condition(s) studied

Investigational drug(s) / intervention(s)

Early de-escalation: In de-escalating group, the empirical antibiotics will be stopped and then prophylaxis levofloxacin will be resumed.

Standard: In the control arm, empirical antibiotics will be continue until recpvery of neutropenia or at least 7 days after afebrile.

Study summary

This is a randomized study to evaluate the safety and feasibility of early de-escalation of empirical antibiotics treatment in neutropenic fever patients undergoing hematopoietic stem cell transplantation (HSCT). In case of afebrile for 72 hours with empirical antibiotics treatment, patients will be randomized into 2 groups. In the early de-escalation group, antibiotics treatment will be stopped and prophylaxis with levofloxacin will be resumed. In the control group, the empirical treatment will continue until recovery of neutropenia or at least for 7 days.

Eligibility

Primary outcome measure(s)

• Days of no empirical antibiotics treatment — 28 days
  days from start of empirical antibiotics to end of study minus days with empirical antibiotics

Trial sites (1)

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