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Clinical Trials in China / NCT04153539
Active, not recruiting Not applicable

Acute Health Effects of Traffic-Related Air Pollution Exposure

NCT04153539 · tracked via the Priya Life Science China tracker
Sponsor
Fudan University
Phase
Not applicable
Started
2019-10-09
Last updated
2026-09-02

Condition(s) studied

Cardiovascular SystemRespiratory System

Investigational drug(s) / intervention(s)

Walking along a busy roadWalking in a traffic-free park

Walking along a busy road: The intervention group will walk along a busy road and be exposed to traffic-related air pollution for 4.5 hours (from 13:00 to 17:30), while alternating 15-minute walking and 30-minute rest periods.

Walking in a traffic-free park: The control group will walk in a traffic-free park for 4.5 hours (from 13:00 to 17:30), while alternating 15-minute walking and 30-minute rest periods.

Study summary

This study aims to assess the effects of acute exposure to traffic-related air pollution and the underlying mechanisms.

Eligibility

Sex
ALL
Min age
18 Years
Max age
30 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Living in Shanghai during the study period; * Body mass index \> 18.5 and ≤ 28; * Non-smoking, no history of alcohol or drug abuse; * Completing the walking task we required. Exclusion Criteria: * Current or ever smokers; * Subjects with allergic disease, such as allergic rhinitis, allergic asthma, and atopy; * Subjects with cardiovascular disease, such as congenital heart disease, pulmonary heart disease, and hypertension; * Subjects with respiratory disease, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease; * Subjects wih chronic disease, such as diabetes, chronic hepatitis, and kidney disease; * Subjects with a history of major surgery; * Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65); * Medication use or dietary supplements intake in recent two months;

Primary outcome measure(s)

  • Changes in FEV1 — FEV1 will be examined before exposure, half an hour after exposure and 12 hours after exposure.
    We plan to measure changes in forced expiratory volume in 1 second.
  • Blood Pressure — Blood pressure will be measured for 24 hours from 8:00 am on the morning of intervention to 8:00 am on the next morning.
    We plan to measure systolic blood pressure (SBP) and diastolic blood pressure (DBP).
  • Heart Rate Variability Parameters — Volunteers will be asked to wear electrographic Holter monitors for 24 hours from 8:00 am on the morning of intervention to 8:00 am on the next morning.
    We plan to measure heart rate variability (HRV) parameters.

Trial sites (1)

FacilityCityRegionStatus
Department of Environmental Health, School of Public Health, Fudan University Shanghai Shanghai Municipality

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Other trials for the same condition

Acute Health Effects of Low Temperature Exposure Active, not recruiting
Acute Effects of Cold Exposure on Cardiovascular System Recruiting
Acute Health Effects of High Temperature Exposure Active, not recruiting
The Effects of Daytime, Nighttime, and Combined Heat Exposure on Human Health Recruiting
Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04153539 on ClinicalTrials.gov ↗ ← All trials in China