Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Condition(s) studied
Investigational drug(s) / intervention(s)
acetaminophen: Patient receive IV acetaminophen (and oral placebo) or placebo IV acetaminophen and oral acetaminophen. All drugs are blinded
Study summary
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.
Eligibility
Primary outcome measure(s)
- post operative delirium — up to 7 days
measured with CAMICU or CAM
Trial sites (8)
| Facility | City | Region | Status |
|---|---|---|---|
| University of British Columbia | Vancouver | British Columbia | Active Not Recruiting |
| University of Manitoba | Winnipeg | Manitoba | Recruiting |
| Trillium Health Centre | Mississagua | Ontario | Not Yet Recruiting |
| University of Ottawa | Ottawa | Ontario | Not Yet Recruiting |
| Sunnybroook Health Centre | Toronto | Ontario | Not Yet Recruiting |
| McGill Universtiy Health Centre | Montreal | Quebec | Recruiting |
| Universite Montreal | Montreal | Quebec | Recruiting |
| University of Laval | Québec | Quebec | Recruiting |
On this site
📄 Tylenol (acetaminophen) drug profile →More McGill University Health Centre/Research Institute of the McGill University Health Centre trials in Canada
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06613178 on ClinicalTrials.gov ↗ ← All trials in Canada