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Clinical Trials in Brazil / NCT06733714
Recruiting Not applicable

Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

NCT06733714 · tracked via the Priya Life Science Brazil tracker
Sponsor
Universidade Federal do Rio de Janeiro
Phase
Not applicable
Started
2024-12-02
Last updated
2024-12-13

Condition(s) studied

Cognitive DysfunctionAlzheimer DiseaseMild Cognitive ImpairmentCognitive DeclineFrontotemporal DegenerationDementiaDementia, VascularLewy Body DiseaseBeta-AmyloidGFAPTau Protein

Investigational drug(s) / intervention(s)

Transcranial Alternating Current StimulationDigital Cognitive Training

Transcranial Alternating Current Stimulation: An alternate eletric current of 1.6mA in theta frequency is applied in the scalp, using two eletrodes (5x5cm). The eletrodes are located aiming for the left dorsolateral prefrontal Cortex area.

Digital Cognitive Training: Using a tablet, the participant will do exercises that were designed to stimulate cognitive domains, especially attention and memory. In this case, we use the BrainHQ platform.

Study summary

BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.

Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints.

METHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.

Eligibility

Sex
ALL
Min age
50 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Healthy subjects over 50 years old, with cognitive complaints Exclusion Criteria: * Estimated Intelligence Quotient \<80 * Dependence on psychoactive substances (DSM-V) * Severe psychiatric or neurological disorders * Uncorrected visual/hearing problems * History of syncope for an unexplained reason or seizure less than a year ago * Previous stroke * Use of anticoagulants * Intracranial metallic prosthesis or cardiac pacemaker * Any contraindication to performing tACS

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Clínica da Memória - IPUB / UFRJ Rio de Janeiro Rio de Janeiro Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06733714 on ClinicalTrials.gov ↗ ← All trials in Brazil