Vivifrail multicomponent exercise program: Individualized multicomponent home-based training (strength/power, balance, gait, and flexibility) prescribed according to the participant's Vivifrail functional profile.
Study summary
This randomized clinical trial investigates the effects of a home-based multicomponent exercise program (Vivifrail) on physical function, muscle morphology, and cognition in community-dwelling adults aged 90 years and older. Participants are randomized into three groups: Vivifrail at least twice a week, Vivifrail at least three times a week, or a control group. Outcomes are assessed at baseline, 12 weeks, and 24 weeks. The primary outcome is physical function measured by the Short Physical Performance Battery (SPPB).
Eligibility
Sex
ALL
Min age
90 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Aged 90 years or older
* Living in the community (own or family home)
* Able to walk independently or with a walking aid (cane or walker), without third-party assistance
* Minimum cognitive capacity to understand and perform the exercises (MMSE, education-adjusted cutoffs)
* Adequate home conditions to perform the program
* Availability of a family member or caregiver to support the sessions
* Signed informed consent (with legal guardian assistance when needed)
Exclusion Criteria:
* \- Total inability to walk or permanent bedridden condition
* Severe cognitive impairment preventing safe understanding and execution of exercises
* Severe orthopedic, neurological, or rheumatological conditions preventing exercise
* Concurrent participation in another structured exercise program
* Anticipated unavailability (relocation, planned hospitalization, or institutionalization) during the intervention
* Refusal to sign informed consent or absence of a legal guardian when required
Primary outcome measure(s)
Change in physical function measured by the Short Physical Performance Battery (SPPB) total score — Baseline (T0), 12 weeks (T1), and 24 weeks (T2) Total SPPB score ranging from 0 to 12 points (higher scores indicate better lower-extremity physical function), combining balance, gait speed, and chair-stand tests.
Trial sites (2)
Facility
City
Region
Status
Hospital de Clínicas de Porto Alegre (HCPA) - Geriatrics outpatient clinic
Porto Alegre
Rio Grande do Sul
Escola de Educação Física, Fisioterapia e Dança (ESEFID/UFRGS) - and participants' homes
Porto Alegre
Rio Grande do Sul
More Federal University of Rio Grande do Sul trials in Brazil
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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