skin microvascular reactivity: Laser-based method for evaluating non-invasive, operator-independent systemic microvascular function that detects microvascular flow in the skin for the evaluation of systemic vascular endothelial function.
Study summary
The evolution of systemic microvascular reactivity may aid in the comprehension of cardiovascular physiology in heart transplantation patients, and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* capability to understand the objectives of the research and to fulfill the Term of Consent
Exclusion Criteria:
* Pregnancy, acute infection diagnosis, use of circulatory assistance devices
Primary outcome measure(s)
Baseline and post-iontophoresis of acetylcholine endothelium-dependent skin microvascular reactivity — Microvascular reactivity will be evaluated 20-minute rest in the supine position in a temperature-controlled room. Evaluation of systemic microvascular reactivity induced by endothelium-dependent agents. Microvascular reactivity will be evaluated using a non-invasive and operator -independent methodology, named laser speckle contrast imaging, coupled with skin iontophoresis of vasodilator agents. Cutaneous microvascular flow will be measured in arbitrary perfusion units, divided by mean arterial pressure, to yield cutaneous vascular conductance.
Trial sites (1)
Facility
City
Region
Status
Eduardo Tibiriçá
Rio de Janeiro
Brazil
Recruiting
More National Institute of Cardiology, Laranjeiras, Brazil trials in Brazil
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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