Laser Speckle Contrast ImagingHandgrip Dynamometry (Muscle Strength)Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)Single-Leg Balance TestAssessment of Global Cognitive Function
Laser Speckle Contrast Imaging: Investigation of Systemic Endothelial Microvascular Function
Handgrip Dynamometry (Muscle Strength): Serving as a marker of systemic muscle strength and sarcopenia.
Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS): This test will assess the strength and power of the lower limbs.
Single-Leg Balance Test: Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.
Assessment of Global Cognitive Function: Overall cognitive function will be assessed using the Mini-Mental State Examination.
Study summary
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.
Eligibility
Sex
ALL
Min age
60 Years
Max age
100 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
* Baseline blood pressure levels within the normal range (\< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.
Exclusion Criteria:
* Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
* Smoking: Active or quit less than 5 years ago.
* Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
* Surgery or trauma in the last 60 days.
* Renal Dysfunction: Chronic renal failure (estimated by eGFR \< 60 mL/min/1.73m²).
* Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).
Primary outcome measure(s)
Systemic (cutaneous) microcirculatory reactivity. — up to 20 minutes To analyze structural and functional changes in the microcirculation in different ages groups, with emphasis on microvascular endothelial senescence.
Trial sites (1)
Facility
City
Region
Status
Eduardo Tibiriçá
Rio de Janeiro
Brazil
More National Institute of Cardiology, Laranjeiras, Brazil trials in Brazil
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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