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Clinical Trials in Brazil / NCT05909150
Recruiting Phase 2

Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

NCT05909150 · tracked via the Priya Life Science Brazil tracker
Sponsor
Fernando Bacal
Phase
Phase 2
Started
2023-11-08
Last updated
2026-05-06

Condition(s) studied

Heart TransplantationAcute Kidney Injury

Investigational drug(s) / intervention(s)

Sodium chloride solution 3,5%Sodium chloride solution 0,9%

Sodium chloride solution 3,5%: Patients will receive 150 mL HSS 3,5% intravenous twice daily for 3 days after heart transplantation.

Sodium chloride solution 0,9%: Patients will receive 150 mL NS 0,9% intravenous twice daily for 3 days after heart transplantation.

Study summary

The goal of this study is to evaluate if hypertonic saline solution can prevent or attenuate acute kidney injury after heart transplantation in the early postoperative phase.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Hospitalized patients submitted to orthotopic heart transplantation (HT) Exclusion Criteria: * Requirement of renal replacement therapy at the time of HT * Requirement of extracorporeal membrane oxygenation (ECMO) before or immediately after HT * Severe peri-operative mechanical complications * Double transplant (e.g. heart-kidney or heart-lung) * Hypernatremia (Na ≥ 145) * Severe hyponatremia (Na ≤ 120)

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Heart Institute, University of São Paulo. São Paulo Brazil Recruiting

Other trials for the same condition

Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America Recruiting
Continuous Renal Replacement Therapy Intensity in Hyperammonemia Enrolling by invitation
Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery Recruiting
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0 Enrolling by invitation
The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05909150 on ClinicalTrials.gov ↗ ← All trials in Brazil