Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial

Condition(s) studied

Investigational drug(s) / intervention(s)

Implementation of cow's milk in decreasingly heated forms: Implementation of cow's milk in decreasingly heated forms to assess maintained remission of EoE

Implementation of hen's egg in decreasingly heated forms: Implementation of hen's egg in decreasingly heated forms to assess maintained remission of EoE

Study summary

The objective of the study is to study whether the introduction of heated food products (more specifically heated hen's egg and/or cow's milk) in children with EoE would be possible without re-occurrence of the eosinophilic inflammation, while the intake of less heated products might cause disease recidive. Moreover, we would like to study whether the gradual re-introduction of less heated products after the most heated form is tolerated, could lead to tolerance induction in EoE.

Eligibility

Primary outcome measure(s)

• Maintained remission of EoE — 40 weeks
  Primary end-point of the study is to study the number of pedEoE children by inclusion on hen's egg and/or cow's milk free diet with potential remaining remission (\<15 eosinophils/hpf on esophageal biopsies) after 8 weeks (re)introduction of heat-denatured hen's egg and/or cow's milk proteins (introduced sequentially as on the one hand baked egg (cake), hard-boiled egg, omelet and soft-boiled egg and on the other hand 20' cooked cow's milk, 15', 10' and 5' cooked cow's milk).

Trial sites (1)

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