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Clinical Trials in Austria / NCT04842591
Active, not recruiting Observational

Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation

NCT04842591 · tracked via the Priya Life Science Austria tracker
Sponsor
Medical University of Graz
Phase
Observational
Started
2020-12-23
Last updated
2025-04-27

Condition(s) studied

Pulmonary HypertensionKidney TransplantationHaemodialysis

Investigational drug(s) / intervention(s)

exercise echocardiography

exercise echocardiography: All patients will undergo exercise echocardiography during a symptom-limited cardiopulmonary exercise test.

Study summary

The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age: ≥ 18 years * patients listed for first kidney transplantation at the Clinical Division of Nephrology Exclusion Criteria: * Age \< 18 years * combined organ transplantations (heart-kidney, pancreas-kidney etc.) * patients with prior kidney transplantation * high calcium score on cardiac-CT (\> 160 Agatston Score)

Primary outcome measure(s)

  • Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope — Baseline and 1 year after kidney transplantation
    Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography

Trial sites (1)

FacilityCityRegionStatus
Medical University of Graz, Department of Internal Medicine, Division of Pulmonology Graz Austria

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Other trials for the same condition

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure Recruiting
Cell Therapy for Immunomodulation in Kidney Transplantation Active, not recruiting
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD) Recruiting
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension Enrolling by invitation
Clinical Registry for the Characterization of the 'Pulmonary Vascular Phenotype' in Patients With Chronic Obstructive Pulmonary Disease Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04842591 on ClinicalTrials.gov ↗ ← All trials in Austria