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Clinical Trials in Australia / NCT05030207
Recruiting Not applicable

Respiratory Adaptive Computed Tomography: Feasibility Study on Real-Time Gated 4DCT for Lung Cancer Radiotherapy

NCT05030207 · tracked via the Priya Life Science Australia tracker
Sponsor
University of Sydney
Phase
Not applicable
Started
2024-05-15
Last updated
2026-05-19

Condition(s) studied

Lung Cancer

Investigational drug(s) / intervention(s)

Real-time Gated 4DCTConventional 4DCT

Real-time Gated 4DCT: Real-time gated four-dimensional cone beam computed tomography (4DCT) will be conducted at the simulation session. The Real-Time Gated 4DCT will be conducted while the patient moves through the rotating X-ray imager. This method detects and then pauses the CT beam during irregular breathing events.

Conventional 4DCT: Four-dimensional computed tomography (4DCT), the standard of care for modern high-precision stereotactic ablative body radiotherapy (SABR), will be conducted at the simulation session. It will run continuously while the patient moves through the rotating X-ray imager.

Study summary

This study does not involve a therapeutic intervention as standard radiation therapy treatment will be prescribed. This study involves one additional 4DCT scan (i.e. the Real-Time Gated 4DCT scan) acquired immediately before or following the conventional 4DCT scan. This will take place on the day of the patient's treatment simulation, as per the current standard of care. The scanning sequence (i.e. conventional first versus gated first) will be randomised.

The Real-Time Gated 4DCT is anticipated to take longer than the conventional 4DCT scan, due to its gated (beam-pause) nature. However, upper limits for timing will be implemented in the software, and the scan aborted for highly erratic breathing traces that would not benefit from a Real-Time Gated 4DCT scan.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * 18 years or older * Have the ability to give informed consent * A diagnosis of lung cancer with an indication for radiation therapy * Radiation therapy treatment involving the acquisition of a 4DCT scan for treatment planning Exclusion Criteria: * Pregnant women * Patients \<18 years * Patients who in the opinion of the treating physician could not tolerate the extra time on the CT couch for an extra scan

Primary outcome measure(s)

  • The feasibility of using Real-Time Gated 4DCT instead of Conventional 4DCT for planning radiotherapy for lung cancer. — 30 minutes
    A change in the anticipated rate of image artifacts in images acquired from Conventional of 60% to 35% or less in images acquired from Real-Time Gated 4DCT.

Trial sites (1)

FacilityCityRegionStatus
Blacktown Hospital Blacktown New South Wales Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05030207 on ClinicalTrials.gov ↗ ← All trials in Australia