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Clinical Trials in Australia / NCT04676828
Recruiting Not applicable

Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer

NCT04676828 · tracked via the Priya Life Science Australia tracker
Sponsor
University of Aarhus
Phase
Not applicable
Started
2021-12-01
Last updated
2026-02-24

Condition(s) studied

Lung CancerRadiation-Induced DisorderRadiation PneumonitisPulmonary DiseaseLung Function Decreased

Investigational drug(s) / intervention(s)

Single-photon-emission CT scan

Single-photon-emission CT scan: SPECT/CT scan is an established functional modality used in the diagnosis and monitoring of lung disease. SPECT/CT scan images pulmonary circulation, where perfused areas equate with normal functional lung

Study summary

Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * histologically verified lung cancer (small-cell and non-small cell lung cancer) * referred for radiotherapy with curative intent * radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard * concurrent chemotherapy is accepted * patients with oligometastatic disease are allowed, where metastasis have been ablated with surgery or radiotherapy * receiving (chemo)-radiotherapy to the thoracic disease with curative intent * adults over 18, that have given oral and written informed consent before patient registration. Exclusion Criteria: * concurrent immunotherapy * previous radiotherapy to the thorax * other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol

Primary outcome measure(s)

  • Radiation-induced lung toxicity — Measured serially from 1 to 12 months after treatment completion
    crude rate of symptomatic radiation-induced lung toxicity of grade 2 and higher. According to the Common Toxicity Criteria for Adverse Events version 5.0 for radiation pneumonitis, dyspnea, cough, or any other radiation-induced respiratory, thoracic and mediastinal disorder.

Trial sites (2)

FacilityCityRegionStatus
Sydney West Radiation Oncology Network Westmead and Blacktown Hospitals Sydney New South Wales Recruiting
Department of Oncology, Aarhus University Hospital Aarhus Denmark Recruiting

More University of Aarhus trials in Australia

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Other trials for the same condition

Markerless Image Guidance Using Intrafraction Kilovoltage X-ray Imaging Recruiting
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Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung Recruiting
Comparison of Different Types of Surgery in Treating Patients With Stage IA Non-Small Cell Lung Cancer Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04676828 on ClinicalTrials.gov ↗ ← All trials in Australia