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Trackers› Clinical trials› USA
Clinical trial register · United States · industry-sponsored

Industry-sponsored studies with a US investigative site

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors — the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice — all 9112 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 23 Sep 2026, 03:16 UTC
9112
Studies in scope
industry-sponsored, all four open statuses
4950
Recruiting now
open to new participants
2202
Lead sponsors
across recruiting studies
Top states
California 5295 Florida 4397 Illinois 2479 Georgia 2346 Arizona 2231
Narrow the register
Recruitment status
Phase
Lead sponsor
AstraZeneca299 Novartis Pharmaceuticals202 Eli Lilly and Company190 Merck Sharp & Dohme LLC183 AbbVie172
State
California5295 Florida4397 Illinois2479 Georgia2346 Arizona2231
All 51 states
Target enrolment
to
9112 of 9112 studies
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Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
Growth Trial: Study of the Renata Minima Stent
NCT05086016Coarctation of the Aorta, Pulmonary Artery Stenosis
Renata Medical
Not applicable
42
California, Massachusetts, Ohio, Tennessee, Washington
2021-01-14
Recruiting
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells
NCT04150042Pancreatic Adenocarcinoma Metastatic, BRCA1 Mutation, BRCA2 Mutation, Pancreatic Acinar Cell Carcinoma
General Oncology, Inc.
Phase 1
24
Massachusetts, New York
2021-01-13
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
Active, closed
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
NCT04579380Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms
Seagen, a wholly owned subsidiary of Pfizer
Phase 2
217
Arizona, California, Colorado, Florida, Minnesota, Missouri, Nebraska, New York
2021-01-11
Active, closed
A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)
NCT04204616Prurigo Nodularis
Galderma R&D
Phase 3
500
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Kansas
2021-01-11
Active, closed
Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis
NCT04539964Rheumatoid Arthritis
SetPoint Medical Corporation
Phase 3
243
Arizona, California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois
2021-01-11
Active, closed
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
NCT04634877Endometrial Neoplasms
Merck Sharp & Dohme LLC
Phase 3
990
Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois
2021-01-10
Recruiting
Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
NCT04282044Solid Tumor, Adult, Triple Negative Breast Cancer, Colorectal Cancer, Hepatocellular Carcinoma
BioEclipse Therapeutics
Phase 1
60
Arizona, California
2021-01-08
Active, closed
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
NCT04534205Unresectable Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Cancer, Recurrent Head and Neck Cancer
BioNTech SE
Phase 2/3
358
California, Connecticut, District of Columbia, Florida, Georgia, Kentucky, Massachusetts, New Mexico
2021-01-07
Recruiting
A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment
NCT04635111Hepatotoxicity, Tenosynovial Giant Cell Tumor
Daiichi Sankyo
Observational
30
California, Massachusetts, New York, Ohio, Texas
2021-01-07
Active, closed
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
NCT04521231B Cell Precursor Acute Lymphoblastic Leukemia
Amgen
Phase 1/2
181
California, Illinois, Maryland, Michigan, New York, Pennsylvania, Tennessee, Texas
2021-01-04
Active, closed
A Safety and Tolerability Study of Neural Stem Cells (NR1) in Subjects With Chronic Ischemic Subcortical Stroke (ISS)
NCT04631406Ischemic Stroke
Clarion Cells, Inc.
Phase 1/2
27
California
2021-01-04
Recruiting
Microsurfaced Grafts in Deep Burn Wounds
NCT04589442Burns, Wound Heal
CellTherX
Phase 4
20
Georgia
2021-01-04
Recruiting
Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices
NCT04835857Hypertension, Healthy
Dynocardia, Inc
Observational
91
Massachusetts
2021-01-01
Recruiting
NobleStitch EL STITCH Trial is a PFO Comparative Trial
NCT04339699Foramen Ovale, Patent, Stroke, Ischemic
Nobles Medical Technologies II Inc
Not applicable
640
Arizona
2021-01-01
Active, closed
A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations
NCT04639219Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast
AstraZeneca
Phase 2
102
California, Indiana, Massachusetts, New Jersey, New York, Texas, Virginia
2020-12-30
Recruiting
Collection of Samples USOPTIVAL Study
NCT04792684Colorectal Cancer (CRC), Advanced Adenomas (AA)
Universal Diagnostics
Observational
1,300
California, Florida, Illinois, Louisiana, Massachusetts, New York, Pennsylvania, Tennessee
2020-12-30
Active, closed
MYLUNG Consortium Study Protocol 2
NCT05644808Carcinoma, Non-Small-Cell Lung
US Oncology Research
Observational
1,002
Alabama, Colorado, Florida, Illinois, Maryland, Minnesota, New York, Ohio
2020-12-29
Active, closed
Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD
NCT04704921AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
AbbVie
Phase 2/3
671
Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Hawaii
2020-12-29
Active, closed
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumours
NCT04735978Advanced Solid Tumor
Replimune, Inc.
Phase 1
123
Iowa, Pennsylvania, Texas
2020-12-29
Active, closed
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
NCT04538742Metastatic Breast Cancer
AstraZeneca
Phase 1/2
245
Florida, New York, Ohio, Tennessee, Texas, Virginia
2020-12-28
Recruiting
Secukinumab Open Label Roll-over Extension Protocol
NCT04638647Autoimmunity, Inflammation
Novartis Pharmaceuticals
Phase 4
1,000
California, Colorado, Florida, Illinois, Indiana, Maryland, Michigan, Nebraska
2020-12-22
Active, closed
A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors
NCT04707248Renal Cell Carcinoma, Ovarian Tumor
Daiichi Sankyo
Phase 1
179
Arizona, Colorado, Florida, Oklahoma, Tennessee
2020-12-22
Active, closed
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
NCT04607421Neoplasms
Pfizer
Phase 3
841
Arizona, California, Florida, Illinois, Louisiana, Minnesota, Missouri, Nebraska
2020-12-21
Active, closed
A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation
NCT04625270Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
Verastem, Inc.
Phase 2
225
Arizona, California, Connecticut, Florida, Illinois, Maryland, Minnesota, Missouri
2020-12-21
Active, closed
An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors
NCT04305795Recurrent Head and Neck Squamous Cell Carcinoma, Metastatic Head-and-neck Squamous-cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma
Rakuten Medical, Inc.
Phase 1/2
23
Florida, Kentucky, Minnesota, Oregon, Pennsylvania, Tennessee, Texas
2020-12-21
Active, closed
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
NCT04656652Non-small Cell Lung Cancer
Daiichi Sankyo
Phase 3
605
Arizona, California, Florida, Illinois, Indiana, Kentucky, Louisiana, Maryland
2020-12-21
Active, closed
A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers
NCT04626635Advanced Solid Tumors
Regeneron Pharmaceuticals
Phase 1/2
548
California, Colorado, Florida, Illinois, Iowa, Michigan, New Jersey, New York
2020-12-21
Active, closed
Study of Immune Globulin Intravenous (Human) GC5107 in Pediatric Subjects With Primary Humoral Immunodeficiency
NCT04565015Primary Immune Deficiency
GC Biopharma Corp
Phase 3
24
Colorado, Texas, Virginia
2020-12-21
Recruiting
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
NCT04669548Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
Potrero Medical
Observational
2,500
California, District of Columbia, Florida, Kentucky, North Carolina, Ohio
2020-12-21
Active, closed
Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations
NCT04641442NLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 Mutations
Novartis Pharmaceuticals
Phase 2
17
Ohio, Pennsylvania, Texas, Washington
2020-12-18
Active, closed
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
NCT04663308Primary Sclerosing Cholangitis
Mirum Pharmaceuticals, Inc.
Phase 2
182
California, Colorado, District of Columbia, Florida, Massachusetts, Michigan, Minnesota, Mississippi
2020-12-18
Active, closed
Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2
NCT04514861Peripheral Artery Disease
Profusa, Inc.
Not applicable
53
California
2020-12-18
Active, closed
A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guérin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy
NCT04640623Urinary Bladder Neoplasms
Janssen Research & Development, LLC
Phase 2
220
Arizona, California, Colorado, Illinois, Indiana, Kansas, Michigan, New York
2020-12-18
Active, closed
Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules
NCT04171492Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Biodesix, Inc.
Observational
2,000
Colorado, Connecticut, District of Columbia, Indiana, Maryland, Michigan, Minnesota, Missouri
2020-12-18
Recruiting
Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF
NCT04592445Heart Failure With Preserved Ejection Fraction (HFpEF
Axon Therapies, Inc.
Not applicable
150
Alabama, Arizona, California, Georgia, Illinois, Indiana, Louisiana, Michigan
2020-12-18
Active, closed
Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)
NCT04626518Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 1/2
370
California, Connecticut, Illinois, Iowa, Michigan, New York, North Carolina, Pennsylvania
2020-12-17
Active, closed
A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer
NCT04556773Metastatic Breast Cancer
AstraZeneca
Phase 1
138
New York, North Carolina, Tennessee, Texas
2020-12-17
Active, closed
A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer
NCT04351555Non-Small Cell Lung Cancer
AstraZeneca
Phase 3
358
California, Massachusetts, New Hampshire, New York, Texas, Virginia, Washington
2020-12-16
Recruiting
Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities
NCT04683250RET-altered Non Small Cell Lung Cancer, RET-altered Solid Tumors
Taiho Pharmaceutical Co., Ltd.
Phase 1/2
244
California, Massachusetts, Michigan, New York, Tennessee, Texas
2020-12-16
Active, closed
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
NCT04490915Congenital Adrenal Hyperplasia
Neurocrine Biosciences
Phase 3
182
California, Colorado, Georgia, Indiana, Maryland, Massachusetts, Michigan, Minnesota
2020-12-16
Active, closed
Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)
NCT04626479Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 1/2
400
California, Connecticut, Illinois, Iowa, Michigan, New York, North Carolina, Pennsylvania
2020-12-16
Active, closed
Beating Heart Mitral Valve Repair With the HARPOON™ System
NCT04375332Mitral Regurgitation
Edwards Lifesciences
Not applicable
25
California, Georgia, Maryland, Michigan, Minnesota, Oregon, Tennessee, Utah
2020-12-16
Active, closed
A Study of the Combination of Talquetamab and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04586426Multiple Myeloma
Janssen Research & Development, LLC
Phase 1/2
228
Alabama, Arkansas, Colorado, Georgia, Minnesota, Missouri, New York, North Carolina
2020-12-15
Active, closed
Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP)
NCT04562766Immune Thrombocytopenia
Principia Biopharma, a Sanofi Company
Phase 3
232
California, Colorado, Florida, Georgia, Illinois, Kentucky, Massachusetts, New York
2020-12-14
Active, closed
Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]
NCT04645212Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
Adverum Biotechnologies, Inc.
Observational
23
California, Colorado, Florida, Nevada, Pennsylvania, Tennessee, Texas
2020-12-14
Active, closed
A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)
NCT04471727Small-Cell Lung Cancer, Neuroendocrine Carcinoma
Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Phase 1/2
232
California, Colorado, Massachusetts, Michigan, New York, Ohio, Oregon, Tennessee
2020-12-14
Active, closed
A Study to Assess Safety and Efficacy of PRL3-Zumab in Patients With Solid Tumors
NCT04452955Solid Tumor
Intra-IMMUSG Pte Ltd
Phase 2
51
Arizona, California, Kentucky, Nevada
2020-12-12
Active, closed
Atrasentan in Patients With IgA Nephropathy
NCT04573478IgA Nephropathy, Immunoglobulin A Nephropathy
Novartis Pharmaceuticals
Phase 3
404
Alabama, California, Florida, Georgia, Illinois, Indiana, Kentucky, Massachusetts
2020-12-11
Active, closed
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT04652882Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
Vanda Pharmaceuticals
Phase 3
70
California, Colorado, Massachusetts, Missouri, New York, Ohio, South Carolina, Texas
2020-12-09
Recruiting
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
NCT04343313Mitral Valve Insufficiency
Half Moon Medical
Not applicable
30
New York, Ohio, Oregon, Pennsylvania
2020-12-08
Active, closed
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
NCT04624204Small Cell Lung Cancer
Merck Sharp & Dohme LLC
Phase 3
672
Arizona, California, District of Columbia, Florida, Illinois, Indiana, Kentucky, Louisiana
2020-12-08
Active, closed
Efficacy Comparison of Cobolimab + Dostarlimab + Docetaxel to Dostarlimab + Docetaxel to Docetaxel Alone in Participants With Advanced Non-small Cell Lung Cancer Who Have Progressed on Prior Anti-PD-(L)1 Therapy and Chemotherapy
NCT04655976Lung Cancer, Non-Small Cell
GlaxoSmithKline
Phase 2/3
758
California, Connecticut, District of Columbia, Hawaii, Iowa, Kentucky, Nevada, New York
2020-12-08
Recruiting
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab
NCT04590326Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Endometrial Cancer
Regeneron Pharmaceuticals
Phase 1/2
612
California, Florida, Illinois, Massachusetts, Michigan, New York, Ohio, Pennsylvania
2020-12-08
Active, closed
Triac Trial II in MCT8 Deficiency Patients
NCT02396459Allan-Herndon-Dudley Syndrome
Rare Thyroid Therapeutics International AB
Phase 2
22
Oregon, Pennsylvania
2020-12-07
Active, closed
A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder
NCT04658862Urinary Bladder Neoplasms
Janssen Research & Development, LLC
Phase 3
518
California, Colorado, Florida, Georgia, Illinois, Michigan, Nebraska, New Jersey
2020-12-07
Active, closed
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
NCT04794101X-Linked Retinitis Pigmentosa
Janssen Research & Development, LLC
Phase 3
97
California, Florida, Georgia, Massachusetts, Michigan, North Carolina, Pennsylvania, Texas
2020-12-04
Active, closed
A Study of Inebilizumab Efficacy and Safety in IgG4- Related Disease
NCT04540497IgG4 Related Disease
Amgen
Phase 3
135
California, Georgia, Maryland, Massachusetts
2020-12-04
Active, closed
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
NCT04622319HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
Daiichi Sankyo
Phase 3
1,600
California, Florida, Illinois, Kentucky, Louisiana, Maryland, New York, North Carolina
2020-12-04
By invitation
Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction
NCT04798430Cardiovascular Disease With Mention of Arteriosclerosis, Elevated Cholesterol, Familial Hypercholesterolemia
LIB Therapeutics LLC
Phase 3
2,000
Illinois, Ohio
2020-12-03
Recruiting
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
NCT04671771End Stage Renal Disease (ESRD), Kidney Failure, Chronic Renal Disease, Hemodialysis
W.L.Gore & Associates
Not applicable
133
Arizona, Florida, Georgia, Kentucky, Maryland, Massachusetts, New Jersey, New York
2020-12-03
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
NCT04548999Multiple Sclerosis
Hoffmann-La Roche
Phase 3
769
Alabama, Arizona, California, Colorado, Florida, Kentucky, Maryland, Massachusetts
2020-12-03
Recruiting
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
NCT04613596Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer
Mirati Therapeutics Inc.
Phase 2/3
626
Arizona, Arkansas, California, Colorado, Connecticut, District of Columbia, Florida, Georgia
2020-12-02
Recruiting
Evaluate the Continued Safety and Performance of the Foot and Ankle Products
NCT04715139Hyperpronated Foot, Reconstruction Surgeries of the Foot, Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle, Fixation of Small Bone Fragments of the Foot/Ankle
Arthrex, Inc.
Observational
700
California, Illinois, Tennessee, Texas, Virginia
2020-12-01
Active, closed
PARADIGM: Amplatzer Valvular Plug for PVL Closure
NCT04489823Paravalvular Aortic Regurgitation
Abbott Medical Devices
Not applicable
200
Alabama, Georgia, Massachusetts, Minnesota, Missouri, Nebraska, New Jersey, New York
2020-12-01
Active, closed
A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (acelERA Breast Cancer)
NCT04576455Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
Hoffmann-La Roche
Phase 2
303
Georgia, Ohio, Oregon
2020-11-27
Active, closed
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
NCT04544436Multiple Sclerosis
Hoffmann-La Roche
Phase 3
864
Alabama, Arizona, California, Colorado, Florida, Indiana, Kansas, Louisiana
2020-11-26
Active, closed
Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome
NCT04623541Relapsed/Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Richter's Syndrome, Treatment-naïve High Risk Chronic Lymphocytic Leukemia
Genmab
Phase 1/2
194
Alabama, California, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York
2020-11-25
Active, closed
A Study of Galcanezumab (LY2951742) in Participants 12 to 17 Years of Age With Chronic Migraine
NCT04616326Chronic Migraine
Eli Lilly and Company
Phase 3
312
Alabama, Arizona, California, Colorado, Florida, Idaho, Illinois, Kansas
2020-11-25
Recruiting
Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial
NCT04375657Epigenetic Aging, Immunosenescence
Intervene Immune, Inc.
Phase 2
85
California
2020-11-23
Recruiting
A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD) - Non-Ambulatory Cohort
NCT04626674Duchenne Muscular Dystrophy
Sarepta Therapeutics, Inc.
Phase 1
83
Arkansas, California, Florida, Illinois, Missouri, North Carolina, Ohio, Texas
2020-11-23
Recruiting
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
NCT04561518Transthyretin-Mediated Amyloidosis, ATTR Amyloidosis
Alnylam Pharmaceuticals
Observational
1,500
California, Florida, Iowa, Kansas, Maryland, Massachusetts, New York, North Carolina
2020-11-23
Active, closed
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
NCT04567550Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME)
AbbVie
Phase 2
139
Arizona, California, Georgia, Illinois, Maryland, Massachusetts, Nevada, New Jersey
2020-11-20
Active, closed
Study of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults
NCT04636697SARS-CoV-2 Infection
Medicago
Phase 2/3
30,918
Alabama, Arizona, California, District of Columbia, Florida, Georgia, Idaho, Illinois
2020-11-19
Active, closed
Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations
NCT04603001Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelomonocytic Leukemia (CMML), Myeloproliferative Neoplasms (MPNs)
Eli Lilly and Company
Phase 1
260
California, Florida, Illinois, Massachusetts, New York, North Carolina, Tennessee, Texas
2020-11-19
By invitation
Adherus™ Dural Sealant in Spinal Procedures
NCT04498026Spinal Duraplasty
Stryker Craniomaxillofacial
Not applicable
114
California, Florida, Illinois, Minnesota, New York, North Carolina, Pennsylvania, Texas
2020-11-19
Active, closed
FS120 Phase 1/1b Study in Patients With Advanced Malignancies
NCT04648202Advanced Cancer, Metastatic Cancer
invoX Pharma Limited
Phase 1
82
Connecticut, Texas, Utah
2020-11-18
Active, closed
Assessing Durvalumab and FLOT Chemotherapy in Resectable Gastric and Gastroesophageal Junction Cancer
NCT04592913Gastrointestinal Neoplasms, Esophagogastric Junction
AstraZeneca
Phase 3
957
California, Florida, Indiana, Kentucky, Massachusetts, New York, Tennessee, Texas
2020-11-17
By invitation
Post-Market Surveillance Study to Evaluate the Long-Term Safety and Effectiveness of the LVIS Device
NCT05453240Intracranial Aneurysms
Microvention-Terumo, Inc.
Observational
250
California
2020-11-17
Recruiting
Study of PF-07248144 in Advanced or Metastatic Solid Tumors
NCT04606446Locally Advanced or Metastatic ER+ HER2- Breast Cancer, Locally Advanced or Metastatic Castration-resistant Prostate Cancer, Locally Advanced or Metastatic Non-small Cell Lung Cancer
Pfizer
Phase 2
320
Arizona, California, Connecticut, Florida, Kentucky, Tennessee, Texas, Washington
2020-11-16
Active, closed
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
NCT04499248Open-angle Glaucoma, Ocular Hypertension
AbbVie
Phase 1/2
100
Arizona, California, Connecticut, Florida, Georgia, Illinois, Indiana, Massachusetts
2020-11-16
Active, closed
Safety, Activity and Cell Kinetics of CYAD-211 in Patients With Relapsed or Refractory Multiple Myeloma
NCT04613557Relapse/Refractory Multiple Myeloma
Celyad Oncology SA
Phase 1
18
Florida, New York
2020-11-16
Active, closed
IN.PACT™ AV Access Post-Approval Study (PAS002)
NCT04543539Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula
Medtronic
Observational
240
California, Connecticut, District of Columbia, Florida, Iowa, Michigan, Minnesota, New Jersey
2020-11-13
Active, closed
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
NCT04577833Prostatic Neoplasms
Janssen Research & Development, LLC
Phase 1
136
Utah
2020-11-13
Active, closed
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer
NCT04557059Prostatic Neoplasms
Janssen Pharmaceutica N.V., Belgium
Phase 3
691
Arizona, Arkansas, Colorado, Florida, Indiana, Michigan, New York, Ohio
2020-11-12
Recruiting
The ENCIRCLE Trial
NCT04153292Mitral Regurgitation, Mitral Valve Insufficiency
Edwards Lifesciences
Not applicable
900
Alabama, Arizona, California, Colorado, Florida, Georgia, Illinois, Indiana
2020-11-12
Active, closed
Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia
NCT05060341Radiation-induced Xerostomia
MeiraGTx, LLC
Observational
22
California, Massachusetts, North Carolina
2020-11-12
Active, closed
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
NCT06665542Sepsis, Acute Infection
MeMed Diagnostics Ltd.
Observational
2,000
New York, Wisconsin
2020-11-12
Active, closed
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
NCT04644068Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer
AstraZeneca
Phase 1/2
702
Massachusetts, New York, Oklahoma, Texas
2020-11-12
Active, closed
A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer
NCT04644770Prostatic Neoplasms, Adenocarcinoma
Janssen Research & Development, LLC
Phase 1
144
Arizona, California, Florida, Illinois, Louisiana, Minnesota, Nebraska, New York
2020-11-12
Active, closed
Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis
NCT04454658Myelofibrosis (MF)
AbbVie
Phase 1
21
California, New Hampshire, New York, Ohio, Oklahoma, Oregon, Texas, Washington
2020-11-11
Active, closed
A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies
NCT04606381Neoplasms
Janssen Research & Development, LLC
Phase 1
158
California, Indiana, New York, Oregon, Tennessee
2020-11-10
Active, closed
Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)
NCT04408625Frontotemporal Dementia
Prevail Therapeutics
Phase 1/2
35
Florida, Massachusetts, Pennsylvania
2020-11-09
Recruiting
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
NCT04302025Non-small Cell Lung Cancer
Genentech, Inc.
Phase 2
99
California, Colorado, Connecticut, District of Columbia, Florida, Illinois, Massachusetts, Michigan
2020-11-06
Recruiting
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728Lymphoid Malignancies
AVM Biotechnology Inc
Phase 1/2
144
California, Florida, Illinois, Kentucky, Nebraska, Ohio, Tennessee, Texas
2020-11-06
Active, closed
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
NCT04301518Preterm Labor, Preterm Birth
Sera Prognostics, Inc.
Not applicable
6,500
California, Connecticut, Delaware, Florida, Kentucky, Louisiana, Massachusetts, Michigan
2020-11-06
Active, closed
Study to Evaluate the Safety and Efficacy of PF-06939926 for the Treatment of Duchenne Muscular Dystrophy
NCT04281485Duchenne Muscular Dystrophy
Pfizer
Phase 3
114
Arkansas, California, Florida, Iowa, Kansas, North Carolina, Pennsylvania, Utah
2020-11-05
Active, closed
A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies
NCT04072458Mantle Cell Lymphoma, Peripheral T-cell Lymphoma (PTCL), Cutaneous T-cell Lymphoma (CTCL), Chronic Lymphocytic Leukemia (CLL)
Bio-Path Holdings, Inc.
Phase 1
30
Georgia, New York, Tennessee, Texas
2020-11-05
Active, closed
Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL)
NCT04663347Diffuse Large B-Cell Lymphoma, Follicular Lymphoma
Genmab
Phase 1/2
543
Alabama, California, Massachusetts, Michigan, New Jersey, New York, North Carolina, Texas
2020-11-03
Active, closed
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
NCT04512235AL Amyloidosis
Alexion Pharmaceuticals, Inc.
Phase 3
281
Arizona, California, Florida, Indiana, Louisiana, Maryland, Massachusetts, Michigan
2020-11-03
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Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site. Derived from ClinicalTrials.gov. Retrieved 23 September 2026. https://priyalifescience.com/clinical-trials-usa?page=80

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