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Trackers› Clinical trials› USA
Clinical trial register · United States · industry-sponsored

Industry-sponsored studies with a US investigative site

Every industry-sponsored study on the ClinicalTrials.gov registry that lists a US site and is open, about to open, active-but-closed, or enrolling by invitation. This deliberately excludes academic and other non-industry sponsors โ€” the full US registry across all sponsors runs to over 22,000 recruiting studies alone.

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Source: ClinicalTrials.gov. Complete coverage of the industry-sponsored slice โ€” all 9110 matching records are in this view (non-industry sponsors are out of scope by design, not truncated). Synced 22 Sep 2026, 03:16 UTC
9110
Studies in scope
industry-sponsored, all four open statuses
4947
Recruiting now
open to new participants
2198
Lead sponsors
across recruiting studies
Top states
California 5292 Florida 4393 Illinois 2478 Georgia 2343 Arizona 2230
Narrow the register
Recruitment status
Phase
Lead sponsor
AstraZeneca299 Novartis Pharmaceuticals202 Eli Lilly and Company190 Merck Sharp & Dohme LLC183 AbbVie172
State
California5292 Florida4393 Illinois2478 Georgia2343 Arizona2230
All 51 states
Target enrolment
to
9110 of 9110 studies
Download
Status
Study
Lead sponsor
Phase
Enrol
US states
Start
Active, closed
Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1
NCT04954001Neurofibromatosis 1, Plexiform Neurofibroma, NF1
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
Phase 1/2
160
California, Florida, Michigan, South Carolina
2021-03-26
Recruiting
Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors
NCT04665206Solid Tumor, Adult, Mesothelioma, NSCLC
Vivace Therapeutics, Inc
Phase 1/2
434
California, Illinois, Massachusetts, Minnesota, New York, Texas, Virginia
2021-03-24
Recruiting
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
NCT04373564Motor Function, Cognitive Function, Contrast Media
Guerbet
Phase 4
2,076
Arizona, Connecticut, Illinois, Massachusetts, Missouri, North Carolina, Pennsylvania, Texas
2021-03-24
Active, closed
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586023Relapsing Multiple Sclerosis
Hoffmann-La Roche
Phase 3
751
Alabama, Arizona, California, District of Columbia, Florida, Indiana, Kansas, Massachusetts
2021-03-24
Active, closed
A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)
NCT04817007Myelofibrosis
Bristol-Myers Squibb
Phase 1/2
216
California, Florida, Louisiana, Massachusetts, Michigan, New Jersey, North Carolina, Pennsylvania
2021-03-22
Active, closed
Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant Rejection
NCT04727788Kidney Transplant Rejection
Verici Dx
Observational
550
Illinois, Maryland, Michigan, Nebraska, Ohio, Pennsylvania, Tennessee, Washington
2021-03-21
Active, closed
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
NCT04455841Anemia, Post-essential Thrombocythemia Myelofibrosis, Post-polycythemia Vera Myelofibrosis
Incyte Corporation
Phase 1/2
84
California, Georgia, Michigan, Missouri, New York, North Carolina, Tennessee, Texas
2021-03-19
Active, closed
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Versus Placebo Combined With AA-P as First-Line Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer
NCT04691804Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Jiangsu HengRui Medicine Co., Ltd.
Phase 3
496
Alaska, Arizona, California, Florida, Louisiana, Maryland, Michigan, Nebraska
2021-03-18
Active, closed
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
NCT04562870Myelofibrosis
Karyopharm Therapeutics Inc
Phase 2
112
California, Colorado, Illinois, Texas
2021-03-17
Active, closed
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
NCT04586010Relapsing Multiple Sclerosis
Hoffmann-La Roche
Phase 3
746
Alabama, Arizona, California, Colorado, Florida, Illinois, Indiana, Louisiana
2021-03-17
Active, closed
Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis
NCT04713475GM1 Gangliosidosis, GM1 Gangliosidosis, Type I, GM1 Gangliosidosis, Type 2, Beta-Galactosidase-1 (GLB1) Deficiency
Gemma Biotherapeutics
Phase 1/2
26
California, Minnesota, New Jersey, Pennsylvania
2021-03-17
Active, closed
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Multiple Sclerosis and Their Infants
NCT06133049Multiple Sclerosis
Bristol-Myers Squibb
Observational
2,961
Minnesota
2021-03-16
Active, closed
Adjuvant PRGN-2012 in Adult Patients With Recurrent Respiratory Papillomatosis
NCT04724980Recurrent Respiratory Papillomatosis, Papillomavirus Infections, Papillomaviridae
Precigen, Inc
Phase 1/2
38
Maryland
2021-03-16
Active, closed
REgiStry Of the NAtural History of recurreNt periCarditis in pEdiatric and Adult Patients
NCT04687358Recurrent Pericarditis
Kiniksa Pharmaceuticals International, plc
Observational
500
Alaska, Arizona, California, Illinois, Iowa, Maryland, Massachusetts, Michigan
2021-03-16
Recruiting
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Aria CV, Inc
Not applicable
30
California, Indiana, Massachusetts, Minnesota, New York, Ohio, South Carolina, Wisconsin
2021-03-15
Active, closed
Atrasentan in Patients With Proteinuric Glomerular Diseases
NCT04573920IgA Nephropathy, Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease
Novartis Pharmaceuticals
Phase 2
103
California, Colorado, Louisiana, Massachusetts, Minnesota, Nevada, North Carolina, Texas
2021-03-15
Active, closed
Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease
NCT04639050Alzheimers Disease
Hoffmann-La Roche
Phase 1/2
241
Florida, Georgia, Michigan, Pennsylvania, Texas
2021-03-15
Active, closed
Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069)
NCT04708041Papillomavirus Infections
Merck Sharp & Dohme LLC
Phase 3
700
California, Florida, South Carolina, Texas, Washington
2021-03-15
Active, closed
Long-term Follow-Up for RGX-121
NCT04597385Mucopolysaccharidosis II
REGENXBIO Inc.
Observational
27
California, New Jersey, Pennsylvania
2021-03-14
Active, closed
Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD
NCT04591392Heart Septal Defect, Heart Septal Defects, Atrial, Heart Defects, Congenital, Cardiovascular Abnormalities
atHeart Medical
Not applicable
250
Alabama, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana
2021-03-12
Active, closed
A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma
NCT04722146Multiple Myeloma
Janssen Research & Development, LLC
Phase 1
140
Alabama, California, Colorado, Georgia, Indiana, Missouri, New Jersey, New York
2021-03-12
Active, closed
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
NCT04562389Myelofibrosis
Karyopharm Therapeutics Inc
Phase 3
353
Alabama, California, Colorado, Connecticut, District of Columbia, Kentucky, Maryland, Michigan
2021-03-11
Recruiting
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
NCT04715646Epilepsy
UCB Biopharma SRL
Phase 3
70
New York, North Carolina
2021-03-11
Active, closed
Performance and Safety of Exufiber Ag+ and Exufiber on Partial Thickness Burns
NCT04839523Partial-thickness Burn
Molnlycke Health Care AB
Not applicable
44
Arizona, California, District of Columbia, Florida, Massachusetts, Pennsylvania
2021-03-10
Recruiting
Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC
NCT04686305Locally Advanced or Metastatic Non-Small Cell Lung Cancer
AstraZeneca
Phase 1
304
California, Kansas, Maryland, Michigan, New York, Texas, Virginia, Washington
2021-03-09
Active, closed
Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
NCT04666038Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Loxo Oncology, Inc.
Phase 3
238
Alabama, Arizona, California, Colorado, Delaware, Florida, Georgia, Illinois
2021-03-09
Recruiting
Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors
NCT04777994Advanced Solid Tumor Cancer
Calico Life Sciences LLC
Phase 1
248
Arizona, Connecticut, Maryland, Massachusetts, Michigan, New York, North Carolina, Pennsylvania
2021-03-09
Active, closed
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378Colorectal Cancer Stage II, Colorectal Cancer Stage III
BioNTech SE
Phase 2
327
California, Indiana, Minnesota, Ohio, Rhode Island, Tennessee, Texas, Virginia
2021-03-08
Recruiting
Preimplantation Genetic Testing in Women of Advanced Maternal Age
NCT04167748Infertility, Female
Genomic Prediction Inc.
Not applicable
240
Florida
2021-03-05
Recruiting
Observational, Passive Surveillance Program to Collect Information on Women and Their Offspring Exposed to MenQuadfiยฎ During Pregnancy, in United States (US)
NCT04843111Meningococcal Infection
Sanofi Pasteur, a Sanofi Company
Observational
50
Pennsylvania
2021-03-05
Active, closed
TH1902 in Patients With Advanced Solid Tumors
NCT04706962Solid Tumor, TNBC - Triple-Negative Breast Cancer, Hormone Receptor-positive Breast Cancer, Epithelial Ovarian Cancer
Theratechnologies
Phase 1
70
Michigan, Pennsylvania, Texas
2021-03-04
Active, closed
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
NCT04775082Obesity
Novo Nordisk A/S
Phase 3
78
Arizona, Colorado, Idaho, Louisiana, Maryland, Minnesota, New York, Ohio
2021-03-04
Recruiting
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
NCT04710576Chronic Graft-versus-host-disease
Syndax Pharmaceuticals
Phase 2
296
Alabama, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Louisiana
2021-03-04
Recruiting
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
NCT04678648Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer, Colon Cancer
RasCal Therapeutics, Inc.
Phase 1
134
California, Colorado, Tennessee
2021-03-03
Active, closed
A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma
NCT04594642B-cell Non Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma
AstraZeneca
Phase 1
226
Florida, Kentucky, New Jersey, North Carolina, Ohio, Pennsylvania, Texas, Wisconsin
2021-03-02
Active, closed
A Clinical Trial Comparing the BAGUERA C to the Marketed Mobi-Cยฎ for the Treatment of Cervical Disc Disease at 2 Contiguous Levels
NCT04564885Cervical Disc Disease
Spineart USA
Not applicable
300
Arizona, California, Colorado, Connecticut, District of Columbia, Georgia, Illinois, Indiana
2021-03-02
Recruiting
Real World Evidence Clinical Utility Study of KidneyIntelX
NCT04802395Chronic Kidney Diseases, Diabetic Kidney Disease
Renalytix AI, Inc.
Observational
10,000
New York
2021-03-02
Active, closed
Assessment of a Large US EHR Database as Meeting FDA Fit-for-Purpose Requirements to Provide External Controls for Study BPM31510 in Participants With Glioblastoma
NCT07674095Glioblastoma
BPGbio
Observational
150
Massachusetts
2021-03-01
Active, closed
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231Carcinoma, Renal Cell
Merck Sharp & Dohme LLC
Phase 3
747
Arizona, California, District of Columbia, Florida, Georgia, Illinois, Indiana, Kentucky
2021-02-25
Recruiting
HeartStart HS1 Defibrillator* Event Registry
NCT04840797Sudden Cardiac Arrest
Heartstream US LLC
Observational
1,400
Pennsylvania
2021-02-25
Active, closed
Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment
NCT04647526Metastatic Castration-Resistant Prostate Cancer
POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company
Phase 3
455
Arizona, California, Colorado, Florida, Iowa, Kentucky, Louisiana, Maryland
2021-02-25
Active, closed
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
NCT04717414Myeloproliferative Disorders, Myelofibrosis, Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
Celgene
Phase 3
313
California, Florida, Illinois, Kentucky, Michigan, Missouri, New Jersey, New York
2021-02-25
Active, closed
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
NCT04699188KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung
Novartis Pharmaceuticals
Phase 1/2
344
Georgia, Massachusetts, Pennsylvania, Texas
2021-02-24
Active, closed
Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
NCT04696731Advanced/Metastatic Clear Cell Renal Cell Carcinoma
Allogene Therapeutics
Phase 1
120
California, Connecticut, District of Columbia, Florida, Michigan, New York, Oregon, Texas
2021-02-24
Active, closed
Study of AZD2811 + Durvalumab in ES-SCLC
NCT04745689Small-Cell Lung Cancer
AstraZeneca
Phase 2
31
Michigan
2021-02-23
Active, closed
A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
NCT04408638Diffuse Large B-cell Lymphoma
Hoffmann-La Roche
Phase 3
270
Alabama, California, Florida, Maryland, Massachusetts, Mississippi, New Jersey, New York
2021-02-23
Active, closed
A Pivotal Study of Safety and Effectiveness of NanoKnife IRE for Stage 3 Pancreatic Cancer
NCT03899636Stage III Pancreatic Cancer
Angiodynamics, Inc.
Phase 3
528
Florida, Illinois, Kentucky, Pennsylvania, Texas
2021-02-23
Active, closed
Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms
NCT04279847Myelofibrosis, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome, Myeloproliferative Neoplasm
Incyte Corporation
Phase 1
140
Alabama, Colorado, Florida, Georgia, Iowa, Missouri, New Jersey, New York
2021-02-23
Active, closed
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
NCT04685135Metastatic Non Small Cell Lung Cancer, Advanced Non Small Cell Lung Cancer
Mirati Therapeutics Inc.
Phase 3
453
California, Colorado, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky
2021-02-23
Active, closed
Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A
NCT04644575Hemophilia A
Bioverativ, a Sanofi company
Phase 3
261
California, Florida, Georgia, Illinois, Iowa, Michigan, Nevada, New York
2021-02-23
Recruiting
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL
NCT04502394Diffuse Large B Cell Lymphoma, Chronic Lymphocytic Leukemia, Non Hodgkin Lymphoma
Kartos Therapeutics, Inc.
Phase 1/2
84
Indiana, Ohio, Texas
2021-02-23
Active, closed
Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors
NCT04721015Advanced Solid Tumors Cancer, Non Small Cell Lung Cancer (NSCLC)
AbbVie
Phase 1
81
Massachusetts, Missouri, North Carolina, Rhode Island, Texas, Virginia
2021-02-23
Recruiting
Single-Sided Deafness and Asymmetric Hearing Loss
NCT04506853Hearing Loss, Unilateral, Hearing Loss, Sensorineural
Med-El Corporation
Not applicable
65
Illinois, Iowa, New York, North Carolina, Washington
2021-02-22
Recruiting
Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old
NCT04748601Migraine Disorders
Upsher-Smith Laboratories
Phase 4
132
Alabama, California, Colorado, Connecticut, Florida, Michigan, Mississippi, Missouri
2021-02-19
Recruiting
Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions
NCT04905160Heart Failure, ADHF, Acute MI
Aventyn, Inc.
Not applicable
1,000
Arizona
2021-02-18
Active, closed
Study of BBP-418 in Patients With LGMD2I
NCT04800874LGMD2I
ML Bio Solutions, Inc.
Phase 2
14
Virginia
2021-02-18
Active, closed
Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
NCT04562532Coronary Artery Disease
Shanghai MicroPort Medical (Group) Co., Ltd.
Not applicable
1,720
Alabama, Arizona, California, Connecticut, Florida, Georgia, Indiana, Kansas
2021-02-17
Recruiting
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
NCT04545502Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
Vascutek Ltd.
Observational
2,000
Colorado, Florida, Indiana, North Carolina, Ohio, Pennsylvania, Virginia
2021-02-17
Active, closed
Immunogenicity, Safety, Reactogenicity and Persistence of an Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
NCT04732871Respiratory Syncytial Virus Infections
GlaxoSmithKline
Phase 3
1,720
Alabama, Arizona, California, Florida, Indiana, Kansas, Minnesota, Missouri
2021-02-15
By invitation
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
NCT05304728Severe Sepsis, Severe Sepsis Without Septic Shock
Beckman Coulter, Inc.
Observational
40,000
California, Georgia, Indiana, Missouri, New Jersey, North Carolina, Ohio
2021-02-15
Active, closed
SYN-004 Safety and Tolerability in Allo-HCT Subjects
NCT04692181Acute Graft-Versus-Host Reaction Following Bone Marrow Transplant, Prevention of CDI in Adult Patients Being Treated With IV Beta-lactam Antibiotics
Theriva Biologics, Inc.
Phase 1/2
36
Missouri
2021-02-15
Active, closed
Paresthesia-Free Fast-Acting Subperception (FAST) Study
NCT04618471Chronic Pain
Boston Scientific Corporation
Not applicable
177
California, Colorado, Florida, Illinois, Indiana, Louisiana, New York, North Carolina
2021-02-10
Active, closed
DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)
NCT04567420Breast Cancer
Criterium, Inc.
Phase 2
70
Arizona, California, Colorado, Connecticut, Georgia, Louisiana, Nebraska, New Mexico
2021-02-09
By invitation
A Long-Term Extension Study for Participants Previously Treated With EB-101 for the Treatment of RDEB
NCT05708677RDEB
Abeona Therapeutics, Inc
Observational
22
California, Massachusetts
2021-02-09
Active, closed
Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)
NCT04657081Acute Myeloid Leukemia
Taiho Oncology, Inc.
Phase 1/2
101
California, Connecticut, Florida, Illinois, Indiana, Massachusetts, Missouri, New Jersey
2021-02-09
Active, closed
INFINITYโ„ข With ADAPTISโ„ข Technology Study
NCT04594993Arthritis, Rheumatoid
Stryker Trauma and Extremities
Observational
200
Arizona, California, Colorado, Florida, Illinois, New York, Oregon, South Carolina
2021-02-09
Active, closed
Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
NCT04736173Non Small Cell Lung Cancer, Nonsquamous Non Small Cell Lung Cancer, Squamous Non Small Cell Lung Cancer, Lung Cancer
Arcus Biosciences, Inc.
Phase 2
169
Georgia, Texas, Virginia
2021-02-08
Active, closed
Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2
NCT04229979Acute Myeloid Leukemia
Sellas Life Sciences Group
Phase 3
127
Alabama, California, Colorado, Florida, Georgia, Illinois, Louisiana, New York
2021-02-08
Active, closed
Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
NCT04515524Retinopathy of Prematurity
Regeneron Pharmaceuticals
Observational
100
California, New York, Ohio, Rhode Island, Texas, West Virginia
2021-02-05
Active, closed
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
NCT04431726Severe Hemophilia A
Hoffmann-La Roche
Phase 3
55
Arizona, California, Colorado, Louisiana, Michigan, Washington
2021-02-04
Recruiting
A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
NCT04901936Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Hemoglobinuria
Apellis Pharmaceuticals, Inc.
Phase 2
12
Georgia
2021-02-04
Recruiting
Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)
NCT04375800Human Immunodeficiency Virus (HIV) Infection
Merck Sharp & Dohme LLC
Phase 2
84
Colorado, Georgia
2021-02-03
Active, closed
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer
NCT04619004Non-Small Cell Lung Cancer Metastatic, Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
Daiichi Sankyo
Phase 2
277
Arizona, California, Colorado, Florida, Georgia, Illinois, Maryland, Massachusetts
2021-02-02
Active, closed
Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751Advanced or Metastatic NSCLC
AstraZeneca
Phase 1
155
California, Missouri, New Jersey, Ohio, Pennsylvania, Texas, Virginia
2021-02-02
Active, closed
MagnetisMM-3: Study Of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One PI, One IMiD and One Anti-CD38 mAb
NCT04649359Multiple Myeloma
Pfizer
Phase 2
187
California, Florida, Georgia, Illinois, Kentucky, Louisiana, New Jersey, New York
2021-02-02
Active, closed
Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation
NCT04755283Atrial Fibrillation (AF), Stroke
Anthos Therapeutics, Inc.
Phase 2
1,287
Alabama, Connecticut, Florida, Georgia, Kentucky, Maryland, Massachusetts, Michigan
2021-02-02
Recruiting
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
NCT03127267Amyotrophic Lateral Sclerosis
AB Science
Phase 3
495
Alabama, California, Kentucky, Maryland, Massachusetts, Virginia
2021-02-02
Recruiting
A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
NCT04634552Hematological Malignancies
Janssen Research & Development, LLC
Phase 2
510
Alabama, Arkansas, California, Florida, Georgia, Illinois, Kentucky, Michigan
2021-02-01
Recruiting
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
NCT04761120Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Abbott Medical Devices
Observational
550
North Carolina, Wisconsin
2021-02-01
Active, closed
Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma (CHARIOT)
NCT04268706Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent, Hodgkin Disease Refractory, Hodgkin Disease, Pediatric
Tessa Therapeutics
Phase 2
97
California, Illinois, Pennsylvania, Tennessee, Texas
2021-02-01
Active, closed
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
NCT04624659Sickle Cell Disease
Forma Therapeutics, Inc.
Phase 3
450
Alabama, Arizona, Arkansas, California, Connecticut, District of Columbia, Florida, Georgia
2021-01-29
Active, closed
A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
NCT04711252ER-Positive HER2-Negative Breast Cancer
AstraZeneca
Phase 3
1,370
Alabama, Arkansas, California, Colorado, Florida, Indiana, Louisiana, Maryland
2021-01-28
Recruiting
Aimovig Pregnancy Exposure Registry
NCT06150781Migraine
Amgen
Observational
2,842
North Carolina
2021-01-27
Active, closed
The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy
NCT04572633Liver Neoplasms, Hepatocellular Carcinoma, Liver Metastases
HistoSonics, Inc.
Not applicable
47
Florida, Illinois, Kansas, Michigan, Wisconsin
2021-01-27
Recruiting
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
NCT04657068Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer
Artios Pharma Ltd
Phase 1/2
542
Alabama, Arizona, Arkansas, California, Colorado, Florida, Illinois, Indiana
2021-01-27
Recruiting
Adjustable Continence Therapy (ACT) for the Treatment of Female SUI
NCT04248283Urinary Incontinence, Urinary Incontinence,Stress
Uromedica
Not applicable
167
Colorado, Nebraska
2021-01-26
Recruiting
BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDAยฎ ) in Treatment of Advanced Malignancies(Keynote-D20)
NCT04752826Advanced Malignancies, Ovarian Cancer, T-cell Lymphoma, Melanoma
BioInvent International AB
Phase 1/2
250
California, New York, Pennsylvania
2021-01-25
Recruiting
Isatuximab in Combination With Novel Agents in RRMM - Master Protocol
NCT04643002Plasma Cell Myeloma Refractory
Sanofi
Phase 1/2
258
Georgia, Illinois, Michigan, New York, Ohio
2021-01-25
Active, closed
Comparing UroLift Experience Against Rezลซm
NCT04338776Benign Prostatic Hyperplasia
NeoTract, Inc.
Not applicable
120
California, Michigan, New York, Texas
2021-01-22
Recruiting
OssiMend BA in Posterolateral Instrumented Lumbar Fusion
NCT04775537Spinal Disease, Degenerative Disc Disease
Collagen Matrix
Observational
120
California, Connecticut, New Jersey, Oregon
2021-01-21
Active, closed
Post-Approval Study of the TREO Abdominal Stent-Graft System
NCT04697784Abdominal Aortic Aneurysm
Bolton Medical
Not applicable
338
Arizona, California, Colorado, Connecticut, District of Columbia, Florida, Georgia, Iowa
2021-01-20
Active, closed
An Open-Label Extension Study of STK-001 for Patients With Dravet Syndrome
NCT04740476Dravet Syndrome
Stoke Therapeutics, Inc
Phase 2
60
California, Colorado, District of Columbia, Florida, Illinois, Iowa, Massachusetts, Michigan
2021-01-20
By invitation
A Long-term Follow-up Study in Participants Who Received CTX001
NCT04208529Beta-Thalassemia, Thalassemia, Sickle Cell Disease, Hematologic Diseases
Vertex Pharmaceuticals Incorporated
Phase 3
160
California, Illinois, New York, North Carolina, Pennsylvania, Tennessee, Texas
2021-01-20
By invitation
Effectiveness of AlloWrapยฎ for the Reduction of Inflammation in ACDF Procedures
NCT04684901Cervical Stenosis, Spondylolisthesis, Cervical Radiculopathy, Cervical Disc Disorder
AlloSource
Not applicable
50
California
2021-01-18
Active, closed
Trial of ERapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance
NCT04230499Familial Adenomatous Polyposis
Rapamycin Holdings Inc.
Phase 2
30
Michigan, Ohio, Texas
2021-01-18
Active, closed
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
NCT04589845Solid Tumors
Hoffmann-La Roche
Phase 2
920
Arizona, California, Georgia, Idaho, Illinois, Indiana, Maryland, Michigan
2021-01-18
Active, closed
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
NCT04657991Melanoma
Pfizer
Phase 3
257
Florida, Kansas, Massachusetts, Ohio, Tennessee
2021-01-15
Recruiting
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
NCT04649242Pediatric Migraine
Pfizer
Phase 3
2,100
Alabama, Arizona, California, Colorado, Connecticut, Delaware, District of Columbia, Florida
2021-01-15
Active, closed
Growth Trial: Study of the Renata Minima Stent
NCT05086016Coarctation of the Aorta, Pulmonary Artery Stenosis
Renata Medical
Not applicable
42
California, Massachusetts, Ohio, Tennessee, Washington
2021-01-14
Active, closed
A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)
NCT04628494Diffuse Large B-cell Lymphoma
Genmab
Phase 3
483
Indiana, Kentucky, Michigan, Minnesota, New Jersey, North Carolina, Ohio, Texas
2021-01-13
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Priya Life Science (2026). Clinical trial register: industry-sponsored studies with a US investigative site. Derived from ClinicalTrials.gov. Retrieved 22 September 2026. https://priyalifescience.com/clinical-trials-usa?page=79

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Listing here is informational and not medical advice; eligibility is determined by each study team. Compare pay for the teams running these studies in the US Pharma Salary Guide, see who's behind them in the US Company Directory, or track approvals on the FDA Approvals Tracker. For Irish, UK and EU sites, see the Ireland, UK and EU registers.