Dose Finding Study to Determine if BEZ235 Alone or in Combination With RAD001 Decreases the Incidence of Respiratory Tract Infections in the Elderly

Inclusion Criteria: * Male and female subjects * Age ≥ 85 years * Age ≥ 65 and \< 85 years with one or more of the following conditions: * Asthma * Chronic Obstructive Pulmonary Disease (COPD) * Chronic bronchitis * Type 2 Diabetes Mellitus (T2DM) * Congestive Heart Failure (CHF) New York Heart Association (NYHA) functional classification I-II * Current smoker * One or more emergency room visits or hospitalizations for a RTI during the previous 12 months Exclusion Criteria: * Subjects with medically significant cardiac conditions including NYHA functional classification III-IV * Subjects with Type I diabetes mellitus. * Subjects with clinically significant underlying pulmonary disease other than asthma, GOLD Class I and II COPD or chronic bronchitis * History of malignancy in any organ system within the past 5 years except for the following: * Localized basal cell or squamous cell carcinoma of the skin, prostate cancer confined to the gland, cervical carcinoma in situ, breast cancer localized to the breast. * Subjects with any one of the following: * hemoglobin \< 10.0 g/dL for males and \< 9.0 for females * white blood cell (WBC) count \< 3,500/mm3, * neutrophil count \< 2,000/mm3 * platelet count \< 125,000/mm3 * Subjects with a history of a systemic autoimmune disease or receiving immunosuppressive therapy * Recent surgery other than minor skin surgery * Liver disease or liver injury * History or presence of impaired renal function * History of immunodeficiency diseases * Subjects with active infection * Subjects with a Mini Mental Status Examination (MMSE) score \<24 at screening. * Significant illness (based on the subject's medical history and the clinical judgement of the investigator) which has not resolved within two (2) weeks prior to initial dosing.