To Assess the Efficacy and Safety of Pegcetacoplan for the Prevention of Recurrent C3G or Primary IC-MPGN in Kidney Transplant Recipients
Condition(s) studied
Investigational drug(s) / intervention(s)
Pegcetacoplan: Dose amount based on age and weight Subcutaneous infusion twice-a-week. Adult participants aged 18 years or older at enrolment: 1080 mg Adolescent participants aged 12 to 17 years at enrolment: * Weight ≥50 kg: 1080 mg * Weight 35 to \<50 kg: 648 mg 1st dose, then 810 mg subsequently * Weight 30 to \<35 kg: 540 mg for the first 2 doses, then 648 mg subsequently
Study summary
To assess the efficacy and safety of pegcetacoplan for the prevention of recurrent C3G or primary IC-MPGN in kidney transplant recipients
Eligibility
Primary outcome measure(s)
- Occurrence of Clinically Significant Recurrent Disease — Within 2 years after kidney transplantation
Occurrence of clinically significant recurrent C3 glomerulopathy (C3G) or primary immune-complex membranoproliferative glomerulonephritis (IC-MPGN) following kidney transplantation.
Trial sites (33)
| Facility | City | Region | Status |
|---|---|---|---|
| Real Hospital Português | Recife | Pernambuco | |
| UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu | Botucatu | São Paulo | |
| Hospital das Clinicas da Faculdade de Medicina da USP - HCFMUSP | São Paulo | São Paulo | |
| University of Alberta - Faculty of Medicine & Dentistry | Edmonton | Alberta | |
| St. Paul's Hospital | Vancouver | British Columbia | |
| London Health Sciences Centre (LHSC) - University Hospital | London | Ontario | |
| Toronto General Hospital | Toronto | Ontario | |
| McGill University Health Centre Research Institute | Montreal | Quebec | |
| Helsinki University Central Hospital | Helsinki | Finland | |
| CHU Strasbourg - Nouvel Hôpital Civil | Strasbourg | Bas Rhin | |
| Hopital Rangueil | Toulouse | Haute Garonne | |
| Hopital Lapeyronie pt | Montpellier | Herault | |
| Hopital Claude Huriez - CHU Lille | Lille | Nord | |
| Hôpital Necker - Enfants Malades | Paris | Paris | |
| Hopital Edouard Herriot - CHU Lyon | Lyon | Rhone | |
| Medizinische Hochschule Hannover | Hanover | Lower Saxony | |
| Universitaetsklinikum Koeln | Cologne | North Rhine-Westphalia | |
| Universitaetsklinikum Essen | Essen | North Rhine-Westphalia | |
| Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari | Bari | Bari | |
| Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII) | Bergamo | Bergamo | |
| Ospedale Pediatrico Bambino Gesù | Roma | Roma | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Roma | Roma | |
| King Faisal Specialist Hospital & Research Center | Riyadh | Saudi Arabia | |
| Hospital Universitari Vall d'Hebron - VHIR | Barcelona | Barcelona | |
| Complejo Hospitalario Universitario A Coruña | A Coruña | La Coruña | |
| Hospital Universitario 12 de Octubre | Madrid | Madrid | |
| Hospital Regional Universitario de Malaga | Málaga | Málaga | |
| Hospital de Cruces | Barakaldo | Vizcaya | |
| Centre Hospitalier Universitaire Vaudois (CHUV) | Lausanne | Switzerland | |
| Royal Free Hospital | London | Greater London | |
| Hammersmith Hospital | London | Greater London | |
| Manchester Royal Infirmary | Manchester | Greater Manchester | |
| Freeman Hospital | Newcastle upon Tyne | Tyne & Wear |
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07898774 on ClinicalTrials.gov ↗ ← All trials in the UK