Prevalence of Adrenal Insufficiency and Associated Factors in Rheumatoid Arthritis Patients Using Low-dose Corticosteroids.

Condition(s) studied

Investigational drug(s) / intervention(s)

ACTH stimulation test: ACTH stimulation test with 250 micrograms tetracosactide acetate if plasma cortisole is below 10 mcg/dl

Cortisol: morning fasting plasma cortisol

Study summary

This study aims to investigate the prevalence of adrenal insufficiency in rheumatoid arthritis (RA) patients receiving low-dose corticosteroid therapy and to identify the factors influencing adrenal insufficiency. To this end, the researchers plan to conduct a study comparing the prevalence of adrenal insufficiency and associated factors among RA patients-who are currently receiving low-dose corticosteroid therapy during outpatient follow-up and have consented to participate-by categorizing them into three groups based on the duration of treatment: short (3 weeks-3 months), medium (3-12 months), and long (\>12 months).

Eligibility

Primary outcome measure(s)

• prevalence of adrenal insufficiency — through study completion, an average of 1 year
  The assessment of adrenal insufficiency is conducted in two stages: the morning cortisol level is measured in the first stage, and the ACTH stimulation test is administered to the relevant participants in the second stage.
• DAS-28 — through study completion, an average of 1 year
  Disease activity score for rheumatoid arthritis
• HAQ — through study completion, an average of 1 year
  Health Assessment Questionnaires
• RAPİD-3 — through study completion, an average of 1 year
  Routine Assessment of Patient Index Data 3
• PASI — through study completion, an average of 1 year
  Psoriasis Area Severity Index

Trial sites (1)

More Bursa Yuksek Ihtisas Training and Research Hospital trials in Turkey