Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression

NCT07853989 · tracked via the Priya Life Science Turkey tracker

Sponsor

Namik Kemal University

Phase

Not applicable

Started

2026-10-01

Last updated

2026-10-02

Condition(s) studied

Major Depressive Disorder (MDD)

Investigational drug(s) / intervention(s)

Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation: TMS protocol administered to patients with major depressive disorder.

Study summary

This prospective observational study aims to evaluate changes in psychological defense mechanisms in patients with non-psychotic major depressive disorder (MDD) undergoing repetitive Transcranial Magnetic Stimulation (rTMS) therapy. The study investigates whether rTMS induces a shift from immature to more mature defense mechanisms and assesses how these changes relate to improvements in depressive symptom severity, anxiety levels, and overall functionality at baseline, 1-month, and 3-month follow-ups.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Age between 18 and 65 years * Diagnosis of major depressive disorder without psychotic features according to DSM-5 criteria * Confirmation of diagnosis via SCID-5 * Major depressive disorder as the primary reason for admission * Willingness to participate and signing the written informed consent form Exclusion Criteria: * Presence of contraindications for TMS (e.g., metallic implants) * Known active psychotic symptoms * History of TMS treatment in the past 3 months * Presence of known organic brain syndrome, neurological, or major systemic medical conditions * Presence of known intellectual disability or significant cognitive impairment * Active substance or alcohol use disorder * Illiteracy

Primary outcome measure(s)

Change in Defense Mechanisms (Defense Style Questionnaire - DSQ) — Baseline, 1 month, and 3 months
Evaluates shifts in mature, neurotic, and immature psychological defense mechanism styles in patients with major depressive disorder following TMS treatment.
Change in Disability and Functionality (World Health Organization Disability Assessment Schedule 2.0 - WHODAS 2.0) — Baseline, 1 month, and 3 months
Evaluates level of functional disability across six domains (understanding/communicating, mobility, self-care, getting along, life activities, participation).

Trial sites (1)

Facility	City	Region	Status
Tekirdağ Namik Kemal University Faculty of Medicine, Department of Psychiatry	Tekirdağ	Turkey (Türkiye)

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07853989 on ClinicalTrials.gov ↗ ← All trials in Turkey