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Recruiting Observational

Menstrual Cycle, Menopause, and Pain Perception During Endodontic Treatment

NCT07850167 · tracked via the Priya Life Science Turkey tracker
Phase
Observational
Started
2026-03-10
Last updated
2026-09-30

Condition(s) studied

Pain Perception in Endodontic TreatmentMenstrual CycleMenopause

Study summary

The goal of this observational study is to investigate whether menstrual cycle phases and menopausal status are associated with pain perception in patients undergoing endodontic treatment. The main questions it aims to answer are:

Does pain experienced during endodontic treatment differ according to the phase of the menstrual cycle? Is pain perception during endodontic treatment different between premenopausal and postmenopausal women? Are menstrual cycle phases and menopausal status associated with pain experienced after endodontic treatment?

Participants undergoing endodontic treatment as part of their routine dental care will provide information about their menstrual cycle or menopausal status. Pain will be assessed at different stages of treatment and during the follow-up period after treatment. No treatment will be assigned based on menstrual cycle phase or menopausal status.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Willing to participate in the study * Aged 18 years or older * Having at least one tooth requiring root canal treatment Exclusion Criteria: * Aged under 18 years * No tooth requiring root canal treatment * Male sex * Diagnosis of endometriosis or polycystic ovary syndrome (PCOS) * Use of oral contraceptives * Receiving hormone therapy

Primary outcome measure(s)

  • Pain Intensity Assessed Using the Visual Analog Scale — -Before treatment(baseline) -Immediately after local anesthetic injection -Immediately after completion of endodontic treatment -Postoperative Day 1 -Postoperative Day 2
    Pain intensity will be assessed using the 100-mm Visual Analog Scale (VAS), ranging from 0 to 100 mm, with higher scores indicating greater pain intensity. Pain scores will be compared among participants in the follicular phase, luteal phase, and postmenopausal groups.

Trial sites (1)

FacilityCityRegionStatus
Niğde Omer Halisdemir University Niğde Turkey (Türkiye) Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07850167 on ClinicalTrials.gov ↗ ← All trials in Turkey